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Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
(2019) Elife 8:
MeSH Terms: ATP-Binding Cassette Transporters, Activating Transcription Factor 6, CRISPR-Cas Systems, Endoplasmic Reticulum, HEK293 Cells, Hep G2 Cells, Humans, Organelles, Peroxisomes, Phenotype, Protein Binding, Small Molecule Libraries, Unfolded Protein Response
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas.
Anderson DMG, Ablonczy Z, Koutalos Y, Hanneken AM, Spraggins JM, Calcutt MW, Crouch RK, Caprioli RM, Schey KL
(2017) Sci Rep 7: 17352
MeSH Terms: ATP-Binding Cassette Transporters, Animals, Disease Models, Animal, Endosomes, Humans, Lipids, Lysophospholipids, Lysosomes, Macular Degeneration, Mice, Mice, Knockout, Monoglycerides, Retina, Retinal Pigment Epithelium, Stargardt Disease
Added March 22, 2018
0 Communities
3 Members
0 Resources
15 MeSH Terms
Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase.
Roland BP, Graham TR
(2016) Proc Natl Acad Sci U S A 113: E4460-6
MeSH Terms: ATP-Binding Cassette Transporters, Adenosine Triphosphatases, Amino Acid Sequence, Asparagine, Biological Transport, Cell Membrane, Directed Molecular Evolution, Gain of Function Mutation, Mutagenesis, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Sphingomyelins, Substrate Specificity
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.
Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA, Alzheimer Disease Genetics Consortium
(2016) Alzheimers Dement 12: 233-43
MeSH Terms: ATP-Binding Cassette Transporters, African Americans, Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Chi-Square Distribution, Chromosome Aberrations, Cohort Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Sialic Acid Binding Ig-like Lectin 3
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Bisphosphonates: from softening water to treating PXE.
Moore SN, Tanner SB, Schoenecker JG
(2015) Cell Cycle 14: 1354-5
MeSH Terms: ATP-Binding Cassette Transporters, Alendronate, Animals, Bone Density Conservation Agents, Etidronic Acid, Female, Humans, Male, Pseudoxanthoma Elasticum, Vascular Calcification
Added February 22, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph.
Zhang LS, Xu M, Yang Q, Lou D, Howles PN, Tso P
(2015) Lipids 50: 371-9
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 5, ATP Binding Cassette Transporter, Subfamily G, Member 8, ATP-Binding Cassette Transporters, Animals, Biological Transport, Body Composition, Cholesterol, Dietary Fats, Gene Knockout Techniques, Intestine, Small, Lipoproteins, Lymph, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Triglycerides
Added August 24, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs.
Allen RM, Vickers KC
(2014) Arterioscler Thromb Vasc Biol 34: 1795-7
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 1, ATP-Binding Cassette Transporters, Animals, Atherosclerosis, Cholesterol, Humans, Lipoproteins, Macrophages, Male, MicroRNAs, Transcription Factor AP-1, Ubiquinone
Added February 12, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms
ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.
Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM
(2014) Am J Physiol Cell Physiol 307: C684-98
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters, Animals, Cells, Cultured, Humans, Lung, Mesenchymal Stem Cells, Mice, Myofibroblasts, Neoplasm Proteins, Pericytes, Pulmonary Fibrosis, Transforming Growth Factor beta1
Added January 20, 2015
2 Communities
5 Members
0 Resources
13 MeSH Terms
Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter.
Mishra S, Verhalen B, Stein RA, Wen PC, Tajkhorshid E, Mchaourab HS
(2014) Elife 3: e02740
MeSH Terms: ATP-Binding Cassette Transporters, Adenosine Triphosphate, Carrier Proteins, Catalytic Domain, Cell Membrane, Cloning, Molecular, Gene Expression Regulation, Hydrolysis, Molecular Dynamics Simulation, Nanotechnology, Nucleotides, Protein Conformation, Protein Multimerization
Added May 30, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
High resolution MALDI imaging mass spectrometry of retinal tissue lipids.
Anderson DM, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL
(2014) J Am Soc Mass Spectrom 25: 1394-403
MeSH Terms: ATP-Binding Cassette Transporters, Animals, Cyclotrons, Diagnostic Imaging, Fourier Analysis, Lipids, Macular Degeneration, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Photoreceptor Cells, Vertebrate, Retina, Retinal Neurons, Retinal Pigment Epithelium, Retinoids, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Stargardt Disease, Tandem Mass Spectrometry
Added May 20, 2014
1 Communities
3 Members
0 Resources
18 MeSH Terms