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Inactivation of in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney.
Gewin LS, Summers ME, Harral JW, Gaskill CF, Khodo SN, Neelisetty S, Sullivan TM, Hopp K, Reese JJ, Klemm DJ, Kon V, Ess KC, Shi W, Majka SM
(2019) Am J Physiol Renal Physiol 317: F1201-F1210
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Cell Lineage, Female, Fibrosis, Kidney Tubules, Proximal, Male, Mice, Myofibroblasts, Polycystic Kidney Diseases, Selective Estrogen Receptor Modulators, Tamoxifen, Tuberous Sclerosis Complex 2 Protein
Added March 18, 2020
0 Communities
2 Members
0 Resources
13 MeSH Terms
Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM
(2019) Clin Pharmacol Ther 106: 623-631
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, Aged, Aged, 80 and over, Allopurinol, Cytokines, Ethnicity, Female, Genome-Wide Association Study, Glucose Transport Proteins, Facilitative, Humans, Male, Middle Aged, Neoplasm Proteins, Oxypurinol, Prognosis, Uric Acid
Added March 24, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.
Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM
(2017) J Clin Invest 127: 2262-2276
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Bone Morphogenetic Protein Receptors, Type II, Cell Differentiation, Cell Lineage, Cells, Cultured, Humans, Lung, Mesenchymal Stem Cells, Mice, Transgenic, Microvessels, Neovascularization, Pathologic, Pericytes, Protein Stability, Pulmonary Fibrosis, Vasoconstriction, Wnt Signaling Pathway
Added June 6, 2017
0 Communities
3 Members
0 Resources
17 MeSH Terms
ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.
Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM
(2014) Am J Physiol Cell Physiol 307: C684-98
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters, Animals, Cells, Cultured, Humans, Lung, Mesenchymal Stem Cells, Mice, Myofibroblasts, Neoplasm Proteins, Pericytes, Pulmonary Fibrosis, Transforming Growth Factor beta1
Added January 20, 2015
2 Communities
5 Members
0 Resources
13 MeSH Terms
Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration.
Tanaka KK, Hall JK, Troy AA, Cornelison DD, Majka SM, Olwin BB
(2009) Cell Stem Cell 4: 217-25
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters, Animals, Female, Mice, Mice, Inbred C57BL, Muscle Development, Muscle, Skeletal, PAX7 Transcription Factor, Regeneration, Satellite Cells, Skeletal Muscle, Stem Cell Niche, Syndecan-3, Syndecan-4
Added August 4, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe.
Urquhart BL, Ware JA, Tirona RG, Ho RH, Leake BF, Schwarz UI, Zaher H, Palandra J, Gregor JC, Dresser GK, Kim RB
(2008) Pharmacogenet Genomics 18: 439-48
MeSH Terms: ATP Binding Cassette Transporter, Subfamily G, Member 2, ATP-Binding Cassette Transporters, Adolescent, Adult, Caco-2 Cells, Drug Resistance, Neoplasm, Female, Gastrointestinal Agents, HeLa Cells, Humans, Inactivation, Metabolic, Intestinal Mucosa, Male, Metabolic Clearance Rate, Middle Aged, Neoplasm Proteins, Polymorphism, Single Nucleotide, Sulfasalazine, Tissue Distribution
Added March 5, 2014
2 Communities
2 Members
0 Resources
19 MeSH Terms