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HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis.
Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I
(2006) J Am Soc Nephrol 17: 2832-43
MeSH Terms: AIDS-Associated Nephropathy, Animals, Female, Gene Products, nef, Genes, vpr, Glomerulosclerosis, Focal Segmental, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Podocytes, nef Gene Products, Human Immunodeficiency Virus
Added January 25, 2012
2 Communities
2 Members
0 Resources
12 MeSH Terms
Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy.
Zhong J, Zuo Y, Ma J, Fogo AB, Jolicoeur P, Ichikawa I, Matsusaka T
(2005) Kidney Int 68: 1048-60
MeSH Terms: AIDS-Associated Nephropathy, Animals, Female, Gene Expression Regulation, Viral, Genetic Predisposition to Disease, HIV-1, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nephrotic Syndrome, Podocytes, Promoter Regions, Genetic, Transgenes
Added January 25, 2012
1 Communities
2 Members
0 Resources
15 MeSH Terms
Quiz page. HIV-associated nephropathy is the overwhelmingly most likely diagnosis.
Wang Y, Rossini M, Fogo AB
(2004) Am J Kidney Dis 43: A47, e1
MeSH Terms: AIDS-Associated Nephropathy, Adult, Diagnosis, Differential, Humans, Male
Added January 20, 2012
1 Communities
1 Members
0 Resources
5 MeSH Terms