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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.
Adeniji A, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM
(2016) J Med Chem 59: 7431-44
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Aldo-Keto Reductase Family 1 Member C3, Butyrates, Cell Line, Tumor, Dose-Response Relationship, Drug, Drug Discovery, Enzyme Inhibitors, Humans, Hydroxyprostaglandin Dehydrogenases, Molecular Structure, Naphthalenes, Structure-Activity Relationship
Added April 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM
(2013) J Med Chem 56: 2429-46
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Aldo-Keto Reductase Family 1 Member C3, Catalytic Domain, Enzyme Inhibitors, Genes, Reporter, HeLa Cells, Humans, Hydroxyprostaglandin Dehydrogenases, Indomethacin, Male, Models, Molecular, Neoplasm Metastasis, Orchiectomy, Prostatic Neoplasms, Receptors, Androgen, Substrate Specificity
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.
Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY
(2001) Arch Biochem Biophys 386: 1-10
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Animals, Baculoviridae, Blotting, Northern, Blotting, Western, Brain, Carbon, Cell Line, Cloning, Molecular, Humans, Insecta, Kinetics, Liver, Lung, Male, Microsomes, Models, Chemical, Oxygen, Prostate, RNA, Messenger, Recombinant Proteins, Substrate Specificity, Testis, Time Factors, Tissue Distribution, Vitamin A
Added February 25, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties.
Chetyrkin SV, Belyaeva OV, Gough WH, Kedishvili NY
(2001) J Biol Chem 276: 22278-86
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Amino Acid Sequence, Base Sequence, Catalysis, DNA, Complementary, Humans, Microsomes, Molecular Sequence Data, Recombinant Proteins, Sequence Homology, Amino Acid
Added February 25, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Escherichia coli flavodoxin sepharose as an affinity resin for cytochromes P450 and use to identify a putative cytochrome P450c17/3beta-hydroxysteroid dehydrogenase interaction.
Jenkins CM, Pikuleva I, Kagawa N, Waterman MR
(1997) Arch Biochem Biophys 347: 93-102
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Adrenal Cortex, Animals, Cattle, Chromatography, Affinity, Cloning, Molecular, Cytochrome P-450 Enzyme System, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Flavodoxin, Immunoblotting, Peptide Fragments, Protein Binding, Recombinant Proteins, Sepharose, Steroid 17-alpha-Hydroxylase, Steroid 21-Hydroxylase, Steroids
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
3 Beta-hydroxysteroid dehydrogenase-isomerase activity in bovine adrenocortical cells in culture: lack of response to ACTH treatment.
Marston SA, Waterman MR, McCarthy JL
(1985) J Steroid Biochem 22: 789-94
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Adrenal Cortex, Adrenocorticotropic Hormone, Animals, Cattle, Cells, Cultured, Kinetics, Progesterone, Progesterone Reductase, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Proliferating human granulosa-lutein cells in long term monolayer culture: expression of aromatase, cholesterol side-chain cleavage, and 3 beta-hydroxysteroid dehydrogenase.
McAllister JM, Mason JI, Byrd W, Trant JM, Waterman MR, Simpson ER
(1990) J Clin Endocrinol Metab 71: 26-33
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Aromatase, Blotting, Northern, Cell Division, Cells, Cultured, Cholesterol, Colforsin, Corpus Luteum, DNA, Enzyme Induction, Female, Gene Expression Regulation, Enzymologic, Granulosa Cells, Humans, Luteal Cells, Progesterone, RNA, Messenger, Transcription, Genetic
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms