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Results: 1 to 6 of 6

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Conformational selection dominates binding of steroids to human cytochrome P450 17A1.
Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ
(2019) J Biol Chem 294: 10028-10041
MeSH Terms: 17-alpha-Hydroxypregnenolone, 17-alpha-Hydroxyprogesterone, Androstenes, Humans, Kinetics, Protein Conformation, Steroid 17-alpha-Hydroxylase, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
Katagiri M, Kagawa N, Waterman MR
(1995) Arch Biochem Biophys 317: 343-7
MeSH Terms: 17-alpha-Hydroxypregnenolone, 17-alpha-Hydroxyprogesterone, Aldehyde-Lyases, Androgens, Androstenedione, Cell Membrane, Cytochrome P-450 Enzyme System, Cytochromes b5, Dehydroepiandrosterone, Escherichia coli, Humans, Hydroxyprogesterones, Kinetics, Pregnenolone, Progesterone, Recombinant Proteins, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Effects of adrenocorticotropin on 17 alpha-hydroxylase activity and cytochrome P-450(17 alpha) synthesis in bovine adrenocortical cells.
Zuber MX, Simpson ER, Hall PF, Waterman MR
(1985) J Biol Chem 260: 1842-8
MeSH Terms: 17-alpha-Hydroxypregnenolone, Adrenal Cortex, Adrenocorticotropic Hormone, Animals, Bucladesine, Cattle, Cells, Cultured, Cytochrome P-450 Enzyme System, Immunologic Techniques, Kinetics, Pregnenolone, Steroid 17-alpha-Hydroxylase, Steroid Hydroxylases
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Co-induction of 17 alpha-hydroxylase and C-17,20-lyase activities in primary cultures of bovine adrenocortical cells in response to ACTH treatment.
McCarthy JL, Waterman MR
(1988) J Steroid Biochem 29: 307-12
MeSH Terms: 17-alpha-Hydroxypregnenolone, Adrenal Cortex, Adrenocorticotropic Hormone, Aldehyde-Lyases, Animals, Bucladesine, Cattle, Cells, Cultured, Cytochrome P-450 Enzyme System, Dehydroepiandrosterone, Enzyme Induction, Kinetics, Microsomes, Pregnenolone, Steroid 17-alpha-Hydroxylase, Steroid Hydroxylases
Added February 12, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.
Barnes HJ, Arlotto MP, Waterman MR
(1991) Proc Natl Acad Sci U S A 88: 5597-601
MeSH Terms: 17-alpha-Hydroxypregnenolone, Amino Acid Sequence, Animals, Base Sequence, Cattle, Cloning, Molecular, Cytochrome P-450 Enzyme System, DNA, Dehydroepiandrosterone, Escherichia coli, In Vitro Techniques, Molecular Sequence Data, Pregnenolone, Progesterone, Recombinant Proteins, Spectrum Analysis, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms