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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 23

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Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.
Chattopadhyay M, Chowdhury AR, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani NG
(2019) J Biol Chem 294: 10336-10348
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Cytochrome P-450 CYP2D6, Disease Models, Animal, Humans, Male, Methylamines, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Neuroblastoma, Neurons, Neurotoxins, Parkinson Disease, Tumor Cells, Cultured
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.
Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, Thiolat ML, Vescovi AL, Calabresi P, Bezard E, Morelli M, Konradi C, Pasqualetti M, Usiello A
(2017) PLoS One 12: e0181677
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Aged, Aged, 80 and over, Animals, Bipolar Disorder, Brain Chemistry, Case-Control Studies, Female, GTP-Binding Proteins, Humans, Macaca mulatta, Male, Middle Aged, Parkinson Disease, Putamen, RNA, Messenger, Schizophrenia
Added March 14, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG
(2013) J Biol Chem 288: 4436-51
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Adrenergic alpha-Antagonists, Animals, Cell Line, Cytochrome P-450 CYP2D6, Dopamine Agents, Dopaminergic Neurons, Dynamins, Humans, Mice, Mitochondria, Mitochondrial Proteins, Parkinsonian Disorders, Quinidine, Reactive Oxygen Species, Ubiquitin-Protein Ligases
Added March 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates.
Leak RK, Garbett KA, Dettmer AM, Zhang Z, Mirnics K, Cameron JL
(2012) Cell Tissue Res 350: 401-7
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Ceruloplasmin, Corpus Striatum, Female, Macaca mulatta, Motor Activity, Neurotoxins, Parkinson Disease, Secondary
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice.
Dean ED, Mexas LM, Cápiro NL, McKeon JE, DeLong MR, Pennell KD, Doorn JA, Tangpricha V, Miller GW, Evatt ML
(2012) PLoS One 7: e39227
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Corpus Striatum, Dopamine Plasma Membrane Transport Proteins, Dopaminergic Neurons, MPTP Poisoning, Male, Mice, Nerve Tissue Proteins, Neurotoxins, Substantia Nigra, Tyrosine 3-Monooxygenase, Vitamin D
Added September 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.
Ahmed MR, Berthet A, Bychkov E, Porras G, Li Q, Bioulac BH, Carl YT, Bloch B, Kook S, Aubert I, Dovero S, Doudnikoff E, Gurevich VV, Gurevich EV, Bezard E
(2010) Sci Transl Med 2: 28ra28
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Antiparkinson Agents, Behavior, Animal, Dose-Response Relationship, Drug, Dyskinesias, Endocytosis, G-Protein-Coupled Receptor Kinases, Gene Knockdown Techniques, Genetic Therapy, Humans, Lentivirus, Levodopa, Macaca, Oxidopamine, Parkinsonian Disorders, Rats, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rotation, Signal Transduction
Added December 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss.
Garcia BG, Neely MD, Deutch AY
(2010) Cereb Cortex 20: 2423-32
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Analysis of Variance, Animals, Cerebral Cortex, Corpus Striatum, Dendrites, Disease Models, Animal, Dopamine, Excitatory Amino Acid Agents, Fluoresceins, Glutamic Acid, Male, Neurons, Organ Culture Techniques, Organic Chemicals, Oxidopamine, Parkinsonian Disorders, Rats, Rats, Sprague-Dawley, Silver Staining
Added May 27, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms
Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.
Zigmond MJ, Cameron JL, Leak RK, Mirnics K, Russell VA, Smeyne RJ, Smith AD
(2009) Parkinsonism Relat Disord 15 Suppl 3: S42-5
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Disease Models, Animal, Dopamine, Glial Cell Line-Derived Neurotrophic Factor, Humans, Mice, Neurons, Oxidopamine, Parkinson Disease, Secondary, Physical Conditioning, Animal, Rats
Added May 19, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation.
Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA
(2009) Eur J Neurosci 30: 207-16
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Aged, Aged, 80 and over, Animals, Cell Count, Cerebral Cortex, Denervation, Dopamine, Humans, Male, Mice, Mice, Inbred C57BL, Middle Aged, Norepinephrine, Parkinsonian Disorders, Serotonin
Added May 27, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease.
Richardson JR, Caudle WM, Wang M, Dean ED, Pennell KD, Miller GW
(2006) FASEB J 20: 1695-7
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Animals, Newborn, Dieldrin, Disease Models, Animal, Dopamine, Dopamine Plasma Membrane Transport Proteins, Drug Synergism, Female, Lactation, Male, Mice, Neurotoxicity Syndromes, Parkinson Disease, Secondary, Pesticides, Pregnancy, RNA, Messenger, Vesicular Monoamine Transport Proteins
Added September 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms