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•  David Piston

•  Irina Kaverina

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Publications

• Neonatal diabetes mellitus due to complete glucokinase deficiency.
  Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI
  (2001) N Engl J Med 344: 1588-92
• Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.
  Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS, Type 1 Diabetes TrialNet Abatacept Study Group
  (2011) Lancet 378: 412-9
• Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.
  Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL
  (2014) Nature 514: 503-7
• In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
  Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA
  (2008) Nature 455: 627-32
• Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
  Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG
  (2000) Nat Genet 26: 336-40
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
  Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D
  (2012) Nat Genet 44: 406-12, S1
• Cytokine-driven beta-cell production in vivo.
  Worchel HN, Magnuson MA
  (2014) Nat Biotechnol 32: 63-4
• Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
  Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H
  (2014) Nat Biotechnol 32: 76-83
• An encapsulation system for the immunoisolation of pancreatic islets.
  Wang T, Lacík I, Brissová M, Anilkumar AV, Prokop A, Hunkeler D, Green R, Shahrokhi K, Powers AC
  (1997) Nat Biotechnol 15: 358-62
• Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
  Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR
  (1999) Cell 96: 329-39
• Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
  Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K
  (2016) Science 351: 711-4
• Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
  Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH
  (2006) Science 311: 1774-5
• Allosteric activators of glucokinase: potential role in diabetes therapy.
  Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
  (2003) Science 301: 370-3
• Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
  Westermark P, Andersson A, Westermark GT
  (2011) Physiol Rev 91: 795-826
• p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
  Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I
  (2016) Nat Med 22: 412-20
• Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells.
  Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL
  (2018) Nat Cell Biol 20: 1267-1277
• EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
  Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
  (2017) Nat Cell Biol 19: 1313-1325
• Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.
  Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A, Poffenberger G, Aramandla R, Levy SE, Powers AC
  (2014) Cell Metab 19: 498-511
• BuMP-ing up insulin secretion by pancreatic beta cells.
  Gannon M
  (2007) Cell Metab 5: 157-9
• Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
  Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N
  (2006) Cell Metab 4: 143-54
• Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
  Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK
  (2016) Cell Metab 23: 909-20
• PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.
  Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB
  (2009) Cell Metab 10: 110-8
• Insulin signaling in alpha cells modulates glucagon secretion in vivo.
  Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN
  (2009) Cell Metab 9: 350-61
• Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.
  Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC
  (2019) Cell Metab 29: 745-754.e4
• Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.
  Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F
  (2016) Cell Metab 23: 837-51
• SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
  Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD
  (2017) Cell Metab 25: 838-855.e15
• The granular chloride channel ClC-3 is permissive for insulin secretion.
  Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ
  (2009) Cell Metab 10: 316-23
• PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
  Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
  (2006) Cell Metab 4: 491-7
• Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.
  Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, Ashcroft FM, In't Veld P, Saada A, Magnuson MA, Glaser B, Dor Y
  (2014) Cell Metab 19: 109-21
• Control of pancreatic β cell regeneration by glucose metabolism.
  Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y
  (2011) Cell Metab 13: 440-449
• Chemicals turn human embryonic stem cells towards beta cells.
  Yang YP, Wright C
  (2009) Nat Chem Biol 5: 195-6
• Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.
  Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A
  (2007) Dev Cell 12: 457-65
• Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells.
  Zhu X, Hu R, Brissova M, Stein RW, Powers AC, Gu G, Kaverina I
  (2015) Dev Cell 34: 656-68
• Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles.
  Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G
  (2018) Dev Cell 45: 347-361.e5