Keyword Connections

•  Dale Edgerton
•  Daniel Lark
•  David Piston

•  David Wasserman
•  James May
•  John Stafford

•  Louise Lantier
•  Mark Magnuson
•  Owen McGuinness

Resources

• 12th Annual Glucose Clamping the Conscious Mouse: A Laboratory Course
• 2017 Glucose Clamping the Conscious Mouse: A Laboratory Course
• Insulin tolerance test (ITT)
• MP&B Student-Selected Faculty Seminar

Communities

• Metabolism Interest Group
• Wasserman Lab

Publications

• Neonatal diabetes mellitus due to complete glucokinase deficiency.
  Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI
  (2001) N Engl J Med 344: 1588-92
• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• Regulatory factor linked to late-onset diabetes?
  Dutta S, Bonner-Weir S, Montminy M, Wright C
  (1998) Nature 392: 560
• Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
  Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
  (2001) Nature 413: 131-8
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
  Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D
  (2012) Nat Genet 44: 406-12, S1
• Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis.
  McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue CA, Feinberg AP
  (2017) Nat Genet 49: 367-376
• Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
  Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman ÅK, Morris AP, McCarthy MI, DIAGRAM Consortium, MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M
  (2011) Nat Genet 44: 67-72
• beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
  Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR
  (2002) Nat Genet 31: 111-5
• Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
  Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG
  (2000) Nat Genet 26: 336-40
• An encapsulation system for the immunoisolation of pancreatic islets.
  Wang T, Lacík I, Brissová M, Anilkumar AV, Prokop A, Hunkeler D, Green R, Shahrokhi K, Powers AC
  (1997) Nat Biotechnol 15: 358-62
• Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
  Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR
  (1999) Cell 96: 329-39
• Suppression of aging in mice by the hormone Klotho.
  Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M
  (2005) Science 309: 1829-33
• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  (2006) Science 312: 1656-9
• Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
  Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH
  (2006) Science 311: 1774-5
• Allosteric activators of glucokinase: potential role in diabetes therapy.
  Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
  (2003) Science 301: 370-3
• Global analysis of protein activities using proteome chips.
  Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean RA, Gerstein M, Snyder M
  (2001) Science 293: 2101-5
• Exercise and glycemic control in diabetes.
  Ellis SE, Elasy TA
  (2001) JAMA 286: 2941-2
• Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations.
  Spanos A, Harrell FE, Durack DT
  (1989) JAMA 262: 2700-7
• p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
  Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I
  (2016) Nat Med 22: 412-20
• Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
  Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF
  (2001) Nat Med 7: 699-705
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• Glucagon's yin and yang effects on hepatic glucose production.
  Edgerton DS, Cherrington AD
  (2013) Nat Med 19: 674-5
• Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
  Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
  (2018) Nat Med 24: 1395-1406
• TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
  Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N
  (2006) Nat Med 12: 107-13
• Regulation of net hepatic glucose uptake in vivo.
  Pagliassotti MJ, Cherrington AD
  (1992) Annu Rev Physiol 54: 847-60
• Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.
  Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ
  (2005) Neuron 46: 555-67
• Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
  Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR
  (2000) Mol Cell 6: 87-97
• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
  Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS
  (2004) Circulation 110: 1492-8
• Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
  Ingelsson E, Pencina MJ, Tofler GH, Benjamin EJ, Lanier KJ, Jacques PF, Fox CS, Meigs JB, Levy D, Larson MG, Selhub J, D'Agostino RB, Wang TJ, Vasan RS
  (2007) Circulation 116: 984-92
• Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community.
  Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, D'Agostino RB, Gaziano JM, Vasan RS
  (2007) Circulation 116: 480-8
• Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis.
  Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ
  (2011) Mol Psychiatry 16: 569-81