Keyword Connections

•  Charles Flynn
•  Dale Edgerton
•  David Wasserman
•  Jacek Hawiger

•  Jason Winnick
•  John Stafford
•  Masakazu Shiota
•  Michael VanSaun

•  Stacey Huppert
•  William Russell

Resources

• pAlb.CRE.GH
• pAlb.GH
• pCMV4.GKL1

Communities

• Metabolism Interest Group

Publications

• Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C.
  Rodriguez-Torres M, Jeffers LJ, Sheikh MY, Rossaro L, Ankoma-Sey V, Hamzeh FM, Martin P, Latino Study Group
  (2009) N Engl J Med 360: 257-67
• Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
  Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
  (2001) Nature 413: 131-8
• A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.
  Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH
  (2013) Nature 502: 550-4
• Telomere dysfunction induces metabolic and mitochondrial compromise.
  Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA
  (2011) Nature 470: 359-65
• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• Syk tyrosine kinase required for mouse viability and B-cell development.
  Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T
  (1995) Nature 378: 303-6
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
  Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
  (1999) Nature 400: 886-91
• Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
  Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI
  (1996) Nature 384: 455-8
• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
  Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS
  (2007) Nature 447: 959-65
• Genome-wide association study of blood pressure and hypertension.
  Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM
  (2009) Nat Genet 41: 677-87
• M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
  De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL
  (1995) Nat Genet 11: 447-9
• Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
  Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R
  (2004) Nat Genet 36: 969-77
• Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
  Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE
  (2000) Nat Genet 24: 175-9
• Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
  Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G
  (2005) Nat Genet 37: 1072-81
• Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
  Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D
  (2002) Nat Genet 32: 245-53
• Organ-specific features of natural killer cells.
  Shi FD, Ljunggren HG, La Cava A, Van Kaer L
  (2011) Nat Rev Immunol 11: 658-71
• The protein kinase IKKepsilon regulates energy balance in obese mice.
  Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR
  (2009) Cell 138: 961-75
• AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
  Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR
  (1996) Cell 84: 321-30
• Acetate dependence of tumors.
  Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP
  (2014) Cell 159: 1591-602
• Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.
  Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, Cancer Genome Atlas Research Network
  (2017) Cell 169: 1327-1341.e23
• Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
  Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, MEDIA Consortium, SIGMA T2D Consortium, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES
  (2017) Cell 170: 199-212.e20
• EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.
  Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG
  (2016) Cell 164: 884-95
• Allosteric activators of glucokinase: potential role in diabetes therapy.
  Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF
  (2003) Science 301: 370-3
• Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
  Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ
  (1994) Science 265: 1580-2
• Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  (2006) Science 312: 1656-9
• Metal chelation and inhibition of bacterial growth in tissue abscesses.
  Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, Torres VJ, Anderson KL, Dattilo BM, Dunman PM, Gerads R, Caprioli RM, Nacken W, Chazin WJ, Skaar EP
  (2008) Science 319: 962-5
• TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
  Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD
  (2015) Science 348: aaa2340
• Hdac3 is essential for the maintenance of chromatin structure and genome stability.
  Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW
  (2010) Cancer Cell 18: 436-47
• Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
  Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
  (2007) Nat Med 13: 1193-202
• Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis.
  Jo D, Liu D, Yao S, Collins RD, Hawiger J
  (2005) Nat Med 11: 892-8
• Dissecting the actions of widely used diabetes drugs.
  Unger RH, Berglund ED, Habener JF, Cherrington AD
  (2013) Nat Med 19: 272-3
• Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
  Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
  (2018) Nat Med 24: 1395-1406
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• Glucagon's yin and yang effects on hepatic glucose production.
  Edgerton DS, Cherrington AD
  (2013) Nat Med 19: 674-5
• A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
  Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ
  (2013) Nat Med 19: 1331-1337
• Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
  An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB
  (2004) Nat Med 10: 268-74