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•  W. Jerome

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Publications

• Failure of ACAT inhibition to retard atherosclerosis.
  Fazio S, Linton M
  (2006) N Engl J Med 354: 1307-9
• Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
  Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, JUPITER Study Group
  (2008) N Engl J Med 359: 2195-207
• Inactivating mutations in NPC1L1 and protection from coronary heart disease.
  Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, Meitinger T, Kessler T, Kastrati A, Laugwitz KL, Siscovick D, Rotter JI, Hazen SL, Tracy R, Cresci S, Spertus J, Jackson R, Schwartz SM, Natarajan P, Crosby J, Muzny D, Ballantyne C, Rich SS, O'Donnell CJ, Abecasis G, Sunaev S, Nickerson DA, Buring JE, Ridker PM, Chasman DI, Austin E, Kullo IJ, Weeke PE, Shaffer CM, Bastarache LA, Denny JC, Roden DM, Palmer C, Deloukas P, Lin DY, Tang ZZ, Erdmann J, Schunkert H, Danesh J, Marrugat J, Elosua R, Ardissino D, McPherson R, Watkins H, Reiner AP, Wilson JG, Altshuler D, Gibbs RA, Lander ES, Boerwinkle E, Gabriel S, Kathiresan S
  (2014) N Engl J Med 371: 2072-82
• Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease.
  Rajput-Williams J, Knott TJ, Wallis SC, Sweetnam P, Yarnell J, Cox N, Bell GI, Miller NE, Scott J
  (1988) Lancet 2: 1442-6
• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
  Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS
  (2007) Nature 447: 959-65
• A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
  Cooper MK, Wassif CA, Krakowiak PA, Taipale J, Gong R, Kelley RI, Porter FD, Beachy PA
  (2003) Nat Genet 33: 508-13
• Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
  Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK
  (2012) Cell 151: 138-52
• Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.
  Linton MF, Atkinson JB, Fazio S
  (1995) Science 267: 1034-7
• Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
  Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC
  (2014) Science 344: 58-64
• Neurosteroids: cytochrome P-450scc in rat brain.
  Le Goascogne C, Robel P, Gouézou M, Sananès N, Baulieu EE, Waterman M
  (1987) Science 237: 1212-5
• A rising StAR: an essential role in cholesterol transport.
  Waterman MR
  (1995) Science 267: 1780-1
• The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.
  Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR
  (2012) Science 336: 1168-71
• Teratogen-mediated inhibition of target tissue response to Shh signaling.
  Cooper MK, Porter JA, Young KE, Beachy PA
  (1998) Science 280: 1603-7
• Effects of dietary composition on energy expenditure during weight-loss maintenance.
  Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, Ludwig DS
  (2012) JAMA 307: 2627-34
• Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
  Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF
  (2001) Nat Med 7: 699-705
• Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial.
  Hortobagyi GN, Ueno NT, Xia W, Zhang S, Wolf JK, Putnam JB, Weiden PL, Willey JS, Carey M, Branham DL, Payne JY, Tucker SD, Bartholomeusz C, Kilbourn RG, De Jager RL, Sneige N, Katz RL, Anklesaria P, Ibrahim NK, Murray JL, Theriault RL, Valero V, Gershenson DM, Bevers MW, Huang L, Lopez-Berestein G, Hung MC
  (2001) J Clin Oncol 19: 3422-33
• Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community.
  Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, D'Agostino RB, Gaziano JM, Vasan RS
  (2007) Circulation 116: 480-8
• Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis.
  Ganda A, Magnusson M, Yvan-Charvet L, Hedblad B, Engström G, Ai D, Wang TJ, Gerszten RE, Melander O, Tall AR
  (2013) Circulation 127: 988-96
• On the relationship between cholesterol lowering and coronary disease event rate.
  Fazio S, Linton MF
  (1998) Circulation 98: 2645-6
• Cardiovascular Effects of Androgen Deprivation Therapy for the Treatment of Prostate Cancer: ABCDE Steps to Reduce Cardiovascular Disease in Patients With Prostate Cancer.
  Bhatia N, Santos M, Jones LW, Beckman JA, Penson DF, Morgans AK, Moslehi J
  (2016) Circulation 133: 537-41
• Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
  Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS
  (2004) Circulation 110: 1492-8
• Utility of Nontraditional Risk Markers in Individuals Ineligible for Statin Therapy According to the 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines.
  Yeboah J, Polonsky TS, Young R, McClelland RL, Delaney JC, Dawood F, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC, Psaty BM, Greenland P, Herrington DM
  (2015) Circulation 132: 916-22
• Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates.
  Sellke FW, Armstrong ML, Harrison DG
  (1990) Circulation 81: 1586-93
• Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.
  Mueller PA, Zhu L, Tavori H, Huynh K, Giunzioni I, Stafford JM, Linton MF, Fazio S
  (2018) Circulation 138: 1850-1863
• Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
  Su YR, Dove DE, Major AS, Hasty AH, Boone B, Linton MF, Fazio S
  (2005) Circulation 111: 2373-81
• Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.
  Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
  (2019) Circulation 139: e56-e528
• Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice.
  Zhang W, Yancey PG, Su YR, Babaev VR, Zhang Y, Fazio S, Linton MF
  (2003) Circulation 108: 2258-63
• Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation.
  Tavori H, Fan D, Blakemore JL, Yancey PG, Ding L, Linton MF, Fazio S
  (2013) Circulation 127: 2403-13
• Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.
  Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ
  (2007) Cell Metab 5: 143-9
• A genome-wide association study of the human metabolome in a community-based cohort.
  Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE
  (2013) Cell Metab 18: 130-43
• Utility of Nontraditional Risk Markers in Atherosclerotic Cardiovascular Disease Risk Assessment.
  Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC, Psaty BM, Greenland P, Herrington DM
  (2016) J Am Coll Cardiol 67: 139-147
• Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies.
  Joshi AD, Andersson C, Buch S, Stender S, Noordam R, Weng LC, Weeke PE, Auer PL, Boehm B, Chen C, Choi H, Curhan G, Denny JC, De Vivo I, Eicher JD, Ellinghaus D, Folsom AR, Fuchs C, Gala M, Haessler J, Hofman A, Hu F, Hunter DJ, Janssen HL, Kang JH, Kooperberg C, Kraft P, Kratzer W, Lieb W, Lutsey PL, Darwish Murad S, Nordestgaard BG, Pasquale LR, Reiner AP, Ridker PM, Rimm E, Rose LM, Shaffer CM, Schafmayer C, Tamimi RM, Uitterlinden AG, Völker U, Völzke H, Wakabayashi Y, Wiggs JL, Zhu J, Roden DM, Stricker BH, Tang W, Teumer A, Hampe J, Tybjærg-Hansen A, Chasman DI, Chan AT, Johnson AD
  (2016) Gastroenterology 151: 351-363.e28
• Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
  Purcell-Huynh DA, Farese RV, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG
  (1995) J Clin Invest 95: 2246-57
• Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
  Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV
  (2001) J Clin Invest 107: 163-71
• Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.
  Minor RL, Myers PR, Guerra R, Bates JN, Harrison DG
  (1990) J Clin Invest 86: 2109-16
• Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
  Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RV
  (2000) J Clin Invest 105: 711-9
• Hypercholesterolemia increases endothelial superoxide anion production.
  Ohara Y, Peterson TE, Harrison DG
  (1993) J Clin Invest 91: 2546-51
• Isolation and characterization of hepatic Golgi lipoproteins from hypercholesterolemic rats.
  Swift LL, Manowitz NR, Dunn GD, LeQuire VS
  (1980) J Clin Invest 66: 415-25
• Elevated cholesterol and bile acid synthesis in an adult patient with homozygous familial hypercholesterolemia. Reduction by a high glucose diet.
  Stacpoole PW, Grundy SM, Swift LL, Greene HL, Slonim AE, Burr IM
  (1981) J Clin Invest 68: 1166-71