Keyword Connections

•  Anne Kenworthy
•  David Harrison
•  Deepak Gupta
•  Edward Gould
•  Evan Brittain

•  Mark de Caestecker
•  Matt Luther
•  Meena Madhur
•  Mohamed Saleh
•  Richard Breyer

•  Sergey Dikalov
•  Susan Majka
•  Tracy Hunley

Resources

• Medical Student Summer Training in Nephrology

Communities

• de Caestecker Lab
• Madhur Lab

Publications

• Treatment of Ménétrier's disease with a monoclonal antibody against the epidermal growth factor receptor.
  Burdick JS, Chung E, Tanner G, Sun M, Paciga JE, Cheng JQ, Washington K, Goldenring JR, Coffey RJ
  (2000) N Engl J Med 343: 1697-701
• A novel channelopathy in pulmonary arterial hypertension.
  Ma L, Roman-Campos D, Austin ED, Eyries M, Sampson KS, Soubrier F, Germain M, Trégouët DA, Borczuk A, Rosenzweig EB, Girerd B, Montani D, Humbert M, Loyd JE, Kass RS, Chung WK
  (2013) N Engl J Med 369: 351-361
• The diagnosis and treatment of baroreflex failure.
  Robertson D, Hollister AS, Biaggioni I, Netterville JL, Mosqueda-Garcia R, Robertson RM
  (1993) N Engl J Med 329: 1449-55
• APOL1 risk variants, race, and progression of chronic kidney disease.
  Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ, AASK Study Investigators, CRIC Study Investigators
  (2013) N Engl J Med 369: 2183-96
• An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension.
  Christman BW, McPherson CD, Newman JH, King GA, Bernard GR, Groves BM, Loyd JE
  (1992) N Engl J Med 327: 70-5
• Attenuation of isoproterenol-mediated vasodilatation in blacks.
  Lang CC, Stein CM, Brown RM, Deegan R, Nelson R, He HB, Wood M, Wood AJ
  (1995) N Engl J Med 333: 155-60
• Intensive blood-pressure control in hypertensive chronic kidney disease.
  Appel LJ, Wright JT, Greene T, Agodoa LY, Astor BC, Bakris GL, Cleveland WH, Charleston J, Contreras G, Faulkner ML, Gabbai FB, Gassman JJ, Hebert LA, Jamerson KA, Kopple JD, Kusek JW, Lash JP, Lea JP, Lewis JB, Lipkowitz MS, Massry SG, Miller ER, Norris K, Phillips RA, Pogue VA, Randall OS, Rostand SG, Smogorzewski MJ, Toto RD, Wang X, AASK Collaborative Research Group
  (2010) N Engl J Med 363: 918-29
• Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred.
  Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA, Loyd JE
  (2001) N Engl J Med 345: 319-24
• A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
  SPRINT Research Group, Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT
  (2015) N Engl J Med 373: 2103-16
• Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects.
  Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ
  (1998) N Engl J Med 339: 1285-92
• Intraocular pressure and baroreflex failure.
  Joos KM, Kakaria SK, Lai KS, Shannon JR, Jordan J
  (1998) Lancet 351: 1704
• Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study.
  Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D'Agostino RB, Newton-Cheh C, Yamamoto JF, Magnani JW, Tadros TM, Kannel WB, Wang TJ, Ellinor PT, Wolf PA, Vasan RS, Benjamin EJ
  (2009) Lancet 373: 739-45
• Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
  Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP
  (2012) Nature 482: 98-102
• Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.
  Germain M, Eyries M, Montani D, Poirier O, Girerd B, Dorfmüller P, Coulet F, Nadaud S, Maugenre S, Guignabert C, Carpentier W, Vonk-Noordegraaf A, Lévy M, Chaouat A, Lambert JC, Bertrand M, Dupuy AM, Letenneur L, Lathrop M, Amouyel P, de Ravel TJ, Delcroix M, Austin ED, Robbins IM, Hemnes AR, Loyd JE, Berman-Rosenzweig E, Barst RJ, Chung WK, Simonneau G, Trégouët DA, Humbert M, Soubrier F
  (2013) Nat Genet 45: 518-21
• Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
  Liu C, Kraja AT, Smith JA, Brody JA, Franceschini N, Bis JC, Rice K, Morrison AC, Lu Y, Weiss S, Guo X, Palmas W, Martin LW, Chen YD, Surendran P, Drenos F, Cook JP, Auer PL, Chu AY, Giri A, Zhao W, Jakobsdottir J, Lin LA, Stafford JM, Amin N, Mei H, Yao J, Voorman A, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Larson MG, Grove ML, Smith AV, Hwang SJ, Chen H, Huan T, Kosova G, Stitziel NO, Kathiresan S, Samani N, Schunkert H, Deloukas P, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, Li M, Fuchsberger C, Pattaro C, Gorski M, CKDGen Consortium, Kooperberg C, Papanicolaou GJ, Rossouw JE, Faul JD, Kardia SL, Bouchard C, Raffel LJ, Uitterlinden AG, Franco OH, Vasan RS, O'Donnell CJ, Taylor KD, Liu K, Bottinger EP, Gottesman O, Daw EW, Giulianini F, Ganesh S, Salfati E, Harris TB, Launer LJ, Dörr M, Felix SB, Rettig R, Völzke H, Kim E, Lee WJ, Lee IT, Sheu WH, Tsosie KS, Edwards DR, Liu Y, Correa A, Weir DR, Völker U, Ridker PM, Boerwinkle E, Gudnason V, Reiner AP, van Duijn CM, Borecki IB, Edwards TL, Chakravarti A, Rotter JI, Psaty BM, Loos RJ, Fornage M, Ehret GB, Newton-Cheh C, Levy D, Chasman DI
  (2016) Nat Genet 48: 1162-70
• Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.
  Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, Guiducci C, Kathiresan S, Benjamin EJ, Struck J, Morgenthaler NG, Bergmann A, Blankenberg S, Kee F, Nilsson P, Yin X, Peltonen L, Vartiainen E, Salomaa V, Hirschhorn JN, Melander O, Wang TJ
  (2009) Nat Genet 41: 348-53
• Genome-wide association study of blood pressure and hypertension.
  Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM
  (2009) Nat Genet 41: 677-87
• Molecular basis of human hypertension: role of angiotensinogen.
  Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM
  (1992) Cell 71: 169-80
• Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor.
  Kennedy CR, Zhang Y, Brandon S, Guan Y, Coffee K, Funk CD, Magnuson MA, Oates JA, Breyer MD, Breyer RM
  (1999) Nat Med 5: 217-20
• Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.
  Moslehi JJ, Deininger M
  (2015) J Clin Oncol 33: 4210-8
• Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia.
  Ketch T, Biaggioni I, Robertson R, Robertson D
  (2002) Circulation 105: 2518-23
• Alterations in the coronary circulation in hypertrophied ventricles.
  Marcus ML, Harrison DG, Chilian WM, Koyanagi S, Inou T, Tomanek RJ, Martins JB, Eastham CL, Hiratzka LF
  (1987) Circulation 75: I19-25
• Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension.
  Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ
  (2010) Circulation 122: 2529-37
• Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study.
  Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, Sawyer DB, Levy D, Wilson PW, D'Agostino RB, Framingham Heart Study
  (2003) Circulation 107: 1486-91
• Impact of obesity on plasma natriuretic peptide levels.
  Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW, Vasan RS
  (2004) Circulation 109: 594-600
• Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction.
  Silberman GA, Fan TH, Liu H, Jiao Z, Xiao HD, Lovelock JD, Boulden BM, Widder J, Fredd S, Bernstein KE, Wolska BM, Dikalov S, Harrison DG, Dudley SC
  (2010) Circulation 121: 519-28
• Angiotensin-converting enzyme inhibitors.
  Brown NJ, Vaughan DE
  (1998) Circulation 97: 1411-20
• Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
  Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH
  (2005) Circulation 111: 63-9
• Cardiovascular effects of noncardiovascular drugs.
  Raj SR, Stein CM, Saavedra PJ, Roden DM
  (2009) Circulation 120: 1123-32
• Eplerenone: cardiovascular protection.
  Brown NJ
  (2003) Circulation 107: 2512-8
• Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop.
  Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB, National Heart, Lung and Blood Institute/Office of Rare Diseases
  (2004) Circulation 109: 2947-52
• Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery.
  Fleming GA, Murray KT, Yu C, Byrne JG, Greelish JP, Petracek MR, Hoff SJ, Ball SK, Brown NJ, Pretorius M
  (2008) Circulation 118: 1619-25
• Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community.
  Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, D'Agostino RB, Gaziano JM, Vasan RS
  (2007) Circulation 116: 480-8
• Blood pressure and left ventricular hypertrophy during American-style football participation.
  Weiner RB, Wang F, Isaacs SK, Malhotra R, Berkstresser B, Kim JH, Hutter AM, Picard MH, Wang TJ, Baggish AL
  (2013) Circulation 128: 524-31
• Trends in antihypertensive drug advertising, 1985-1996.
  Wang TJ, Ausiello JC, Stafford RS
  (1999) Circulation 99: 2055-7
• Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance.
  Cogan J, Austin E, Hedges L, Womack B, West J, Loyd J, Hamid R
  (2012) Circulation 126: 1907-16
• Metabolite profiling identifies pathways associated with metabolic risk in humans.
  Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ
  (2012) Circulation 125: 2222-31
• Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.
  Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J
  (2015) Circulation 131: 401-9; discussion 409