Keyword Connections

•  Dale Edgerton

•  Danielle Dean

•  David Wasserman

Resources

• B6.129S6-Gcg{tm1(cre/ERT2)Cshi}/Vu
• Hormone List of Services

Communities

• Metabolism Interest Group

Publications

• Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.
  Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL
  (2014) Nature 514: 503-7
• Glucagon's yin and yang effects on hepatic glucose production.
  Edgerton DS, Cherrington AD
  (2013) Nat Med 19: 674-5
• Dissecting the actions of widely used diabetes drugs.
  Unger RH, Berglund ED, Habener JF, Cherrington AD
  (2013) Nat Med 19: 272-3
• Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells.
  Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL
  (2018) Nat Cell Biol 20: 1267-1277
• Regulation of net hepatic glucose uptake in vivo.
  Pagliassotti MJ, Cherrington AD
  (1992) Annu Rev Physiol 54: 847-60
• GLP-1 analog attenuates cocaine reward.
  Graham DL, Erreger K, Galli A, Stanwood GD
  (2013) Mol Psychiatry 18: 961-2
• Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
  Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC
  (2017) Cell Metab 25: 1362-1373.e5
• Insulin signaling in alpha cells modulates glucagon secretion in vivo.
  Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN
  (2009) Cell Metab 9: 350-61
• Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.
  Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, Ashcroft FM, In't Veld P, Saada A, Magnuson MA, Glaser B, Dor Y
  (2014) Cell Metab 19: 109-21
• The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
  Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD
  (2014) Cell Metab 20: 1018-29
• Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.
  Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A
  (2007) Dev Cell 12: 457-65
• Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
  Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P
  (2013) Dev Cell 26: 86-100
• Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery.
  Albaugh VL, Banan B, Antoun J, Xiong Y, Guo Y, Ping J, Alikhan M, Clements BA, Abumrad NN, Flynn CR
  (2019) Gastroenterology 156: 1041-1051.e4
• Hepatic energy state is regulated by glucagon receptor signaling in mice.
  Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH
  (2009) J Clin Invest 119: 2412-22
• Hepatic β-arrestin 2 is essential for maintaining euglycemia.
  Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J
  (2017) J Clin Invest 127: 2941-2945
• Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon.
  Shulman GI, Liljenquist JE, Williams PE, Lacy WW, Cherrington AD
  (1978) J Clin Invest 62: 487-91
• Effects of morphine on glucose homeostasis in the conscious dog.
  Radosevich PM, Williams PE, Lacy DB, McRae JR, Steiner KE, Cherrington AD, Lacy WW, Abumrad NN
  (1984) J Clin Invest 74: 1473-80
• Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.
  Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson J-L , Perry JM, Lacy WW, Rabinowitz D
  (1977) J Clin Invest 59: 369-74
• Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration.
  Myers SR, McGuinness OP, Neal DW, Cherrington AD
  (1991) J Clin Invest 87: 930-9
• Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle.
  Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH
  (1996) J Clin Invest 98: 125-35
• The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog.
  Cherrington AD, Chiasson JL, Liljenquist JE, Jennings AS, Keller U, Lacy WW
  (1976) J Clin Invest 58: 1407-18
• Hepatic Gi signaling regulates whole-body glucose homeostasis.
  Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J
  (2018) J Clin Invest 128: 746-759
• Effect of glucagon on glucose production during insulin deficiency in the dog.
  Cherrington AD, Lacy WW, Chiasson JL
  (1978) J Clin Invest 62: 664-77
• Epigenomic plasticity enables human pancreatic α to β cell reprogramming.
  Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH
  (2013) J Clin Invest 123: 1275-84
• Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.
  Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E
  (2017) J Clin Invest 127: 4379-4393
• Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.
  Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK
  (2013) J Clin Invest 123: 5061-70
• Comparison of the direct and indirect effects of epinephrine on hepatic glucose production.
  Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD
  (1997) J Clin Invest 99: 1044-56
• Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs.
  Ramnanan CJ, Saraswathi V, Smith MS, Donahue EP, Farmer B, Farmer TD, Neal D, Williams PE, Lautz M, Mari A, Cherrington AD, Edgerton DS
  (2011) J Clin Invest 121: 3713-23
• Role of insulin in the regulation of leucine kinetics in the conscious dog.
  Abumrad NN, Jefferson LS, Rannels SR, Williams PE, Cherrington AD, Lacy WW
  (1982) J Clin Invest 70: 1031-41
• Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.
  Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE, Cherrington AD
  (1980) J Clin Invest 65: 496-505
• Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog.
  Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD
  (1987) J Clin Invest 79: 557-65
• Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.
  Unger RH, Cherrington AD
  (2012) J Clin Invest 122: 4-12
• Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs.
  Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach PJ, Cherrington AD
  (2010) J Clin Invest 120: 4425-35
• Insulin's direct effects on the liver dominate the control of hepatic glucose production.
  Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, Chu CA, Cherrington AD
  (2006) J Clin Invest 116: 521-7