Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L (2011) Genes Dev 25: 2291-305 Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Choi E, Roland JT, Barlow BJ, O'Neal R, Rich AE, Nam KT, Shi C, Goldenring JR (2014) Gut 63: 1711-20 GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation. Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL (2018) Proc Natl Acad Sci U S A 115: 4501-4506 Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity. Dunn JP, Kessler RM, Feurer ID, Volkow ND, Patterson BW, Ansari MS, Li R, Marks-Shulman P, Abumrad NN (2012) Diabetes Care 35: 1105-11 Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample. Ingelsson E, Larson MG, Yin X, Wang TJ, Meigs JB, Lipinska I, Benjamin EJ, Keaney JF, Vasan RS (2008) J Clin Endocrinol Metab 93: 3149-57 Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor. Bender BJ, Vortmeier G, Ernicke S, Bosse M, Kaiser A, Els-Heindl S, Krug U, Beck-Sickinger A, Meiler J, Huster D (2019) Structure 27: 537-544.e4 Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y (2011) Aging Cell 10: 996-1010 Anabolic interventions in ESRD: light at the end of the tunnel? Hakim RM, Ikizler TA (2009) Am J Kidney Dis 54: 201-4 Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humans. Tamboli RA, Antoun J, Sidani RM, Clements A, Harmata EE, Marks-Shulman P, Gaylinn BD, Williams B, Clements RH, Albaugh VL, Abumrad NN (2017) Diabetes Obes Metab 19: 1267-1275 Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice. Garcia JM, Scherer T, Chen JA, Guillory B, Nassif A, Papusha V, Smiechowska J, Asnicar M, Buettner C, Smith RG (2013) Endocrinology 154: 3118-29 Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice. Ma X, Lin Y, Lin L, Qin G, Pereira FA, Haymond MW, Butte NF, Sun Y (2012) Am J Physiol Endocrinol Metab 303: E422-31 Jejunal administration of glucose enhances acyl ghrelin suppression in obese humans. Tamboli RA, Sidani RM, Garcia AE, Antoun J, Isbell JM, Albaugh VL, Abumrad NN (2016) Am J Physiol Endocrinol Metab 311: E252-9 Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver. Hasenour CM, Berglund ED, Wasserman DH (2013) Mol Cell Endocrinol 366: 152-62 Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity. Savage SW, Zald DH, Cowan RL, Volkow ND, Marks-Shulman PA, Kessler RM, Abumrad NN, Dunn JP (2014) Obesity (Silver Spring) 22: 1452-7 Early weight regain after gastric bypass does not affect insulin sensitivity but is associated with elevated ghrelin. Tamboli RA, Breitman I, Marks-Shulman PA, Jabbour K, Melvin W, Williams B, Clements RH, Feurer ID, Abumrad NN (2014) Obesity (Silver Spring) 22: 1617-22 Genetic determinants of pancreatic epsilon-cell development. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P (2005) Dev Biol 286: 217-24 Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin. Vortmeier G, DeLuca SH, Els-Heindl S, Chollet C, Scheidt HA, Beck-Sickinger AG, Meiler J, Huster D (2015) PLoS One 10: e0122444 Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L (2012) PLoS One 7: e52026 Ultrastructure of islet ghrelin cells in the human fetus. Wierup N, Sundler F (2005) Cell Tissue Res 319: 423-8 Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery. Hansen EN, Tamboli RA, Isbell JM, Saliba J, Dunn JP, Marks-Shulman PA, Abumrad NN (2011) Am J Physiol Gastrointest Liver Physiol 300: G795-802 Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis. Ellacott KL, Halatchev IG, Cone RD (2006) Peptides 27: 340-9 Zebrafish ghrelin is expressed in pancreatic endocrine cells and regulated by metabolic state. Eom J, Hong M, Cone RD, Song Y (2013) Biochem Biophys Res Commun 439: 115-20
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.