Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells. Zeng F, Xu J, Harris RC (2009) FASEB J 23: 1935-45 Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA (2014) FASEB J 28: 2177-90 Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. Goulet CC, Volk KA, Adams CM, Prince LS, Stokes JB, Snyder PM (1998) J Biol Chem 273: 30012-7 Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases. Kotorashvili A, Russo SJ, Mulugeta S, Guttentag S, Beers MF (2009) J Biol Chem 284: 16667-16678 NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling. Tanksley JP, Chen X, Coffey RJ (2013) PLoS One 8: e81514
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