Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL (2014) Nature 514: 503-7 Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D (2002) Nat Genet 32: 245-53 Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D (2012) Nat Genet 44: 406-12, S1 Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW (2016) Nat Med 22: 800-6 Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M (2012) J Exp Med 209: 713-28 The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D (2002) J Clin Invest 110: 1839-47 Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors. Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC, Arteaga CL (2013) Cancer Res 73: 1190-200 Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Garrett JT, Chakrabarty A, Arteaga CL (2011) Oncotarget 2: 1314-21 The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Yan L, Guo S, Brault M, Harmon J, Robertson RP, Hamid R, Stein R, Yang E (2012) Biochem J 444: 239-47 Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin. Liu HY, Collins QF, Moukdar F, Zhuo D, Han J, Hong T, Collins S, Cao W (2008) J Biol Chem 283: 12056-63 The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct. Vander Kooi BT, Streeper RS, Svitek CA, Oeser JK, Powell DR, O'Brien RM (2003) J Biol Chem 278: 11782-93 A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1. Nnamani MC, Ganguly S, Erkenbrack EM, Lynch VJ, Mizoue LS, Tong Y, Darling HL, Fuxreiter M, Meiler J, Wagner GP (2016) Cell Rep 15: 2097-2108
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