Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Smider V, Rathmell WK, Lieber MR, Chu G (1994) Science 266: 288-91 Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis. Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M (2012) Mol Cell 46: 573-83 Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Rathmell WK, Chu G (1994) Proc Natl Acad Sci U S A 91: 7623-7 Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S (2007) Cell Death Differ 14: 2058-67 Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization. Gama V, Gomez JA, Mayo LD, Jackson MW, Danielpour D, Song K, Haas AL, Laughlin MJ, Matsuyama S (2009) Cell Death Differ 16: 758-69 Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK (2017) Oncotarget 8: 43733-43751 Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Errami A, Smider V, Rathmell WK, He DM, Hendrickson EA, Zdzienicka MZ, Chu G (1996) Mol Cell Biol 16: 1519-26 A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron. Plesca D, Mazumder S, Gama V, Matsuyama S, Almasan A (2008) J Biol Chem 283: 30796-803 Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis. Gama V, Yoshida T, Gomez JA, Basile DP, Mayo LD, Haas AL, Matsuyama S (2006) Exp Cell Res 312: 488-99 Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. Mårtensson S, Nygren J, Osheroff N, Hammarsten O (2003) Radiat Res 160: 291-301 Bax-inhibiting peptides derived from Ku70 and cell-penetrating pentapeptides. Gomez JA, Gama V, Yoshida T, Sun W, Hayes P, Leskov K, Boothman D, Matsuyama S (2007) Biochem Soc Trans 35: 797-801 Bax-inhibiting peptide derived from mouse and rat Ku70. Yoshida T, Tomioka I, Nagahara T, Holyst T, Sawada M, Hayes P, Gama V, Okuno M, Chen Y, Abe Y, Kanouchi T, Sasada H, Wang D, Yokota T, Sato E, Matsuyama S (2004) Biochem Biophys Res Commun 321: 961-6 Ku70 is stabilized by increased cellular SUMO. Yurchenko V, Xue Z, Gama V, Matsuyama S, Sadofsky MJ (2008) Biochem Biophys Res Commun 366: 263-8
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