Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY (2008) Nature 452: 713-8 Sex-specific roles of beta-catenin in mouse gonadal development. Liu CF, Bingham N, Parker K, Yao HH (2009) Hum Mol Genet 18: 405-17 Genetic modifiers of neurological disease. Kearney JA (2011) Curr Opin Genet Dev 21: 349-53 Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum. Johnson DB, Roszik J, Shoushtari AN, Eroglu Z, Balko JM, Higham C, Puzanov I, Patel SP, Sosman JA, Woodman SE (2016) Pigment Cell Melanoma Res 29: 470-3 Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Ohi MD, Vander Kooi CW, Rosenberg JA, Ren L, Hirsch JP, Chazin WJ, Walz T, Gould KL (2005) Mol Cell Biol 25: 451-60 Removal of a single alpha-tubulin gene intron suppresses cell cycle arrest phenotypes of splicing factor mutations in Saccharomyces cerevisiae. Burns CG, Ohi R, Mehta S, O'Toole ET, Winey M, Clark TA, Sugnet CW, Ares M, Gould KL (2002) Mol Cell Biol 22: 801-15 Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. Ohi MD, Gould KL (2002) RNA 8: 798-815 Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19. Ren L, McLean JR, Hazbun TR, Fields S, Vander Kooi C, Ohi MD, Gould KL (2011) PLoS One 6: e16719 The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Vander Kooi CW, Ohi MD, Rosenberg JA, Oldham ML, Newcomer ME, Gould KL, Chazin WJ (2006) Biochemistry 45: 121-30
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.