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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Kelch-Like ECH-Associated Protein 1 are shown below. Double-click or tap a node for more information.
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- NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML
(2003) Cancer Res 63: 5636-45 - Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2.
Sekhar KR, Yan XX, Freeman ML
(2002) Oncogene 21: 6829-34 - Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J
(2012) Free Radic Biol Med 52: 462-72 - Suppressed ubiquitination of Nrf2 by p47 contributes to Nrf2 activation.
Ha Kim K, Sadikot RT, Yeon Lee J, Jeong HS, Oh YK, Blackwell TS, Joo M
(2017) Free Radic Biol Med 113: 48-58 - Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
Gao L, Wang J, Sekhar KR, Yin H, Yared NF, Schneider SN, Sasi S, Dalton TP, Anderson ME, Chan JY, Morrow JD, Freeman ML
(2007) J Biol Chem 282: 2529-37 - Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation.
Hong F, Sekhar KR, Freeman ML, Liebler DC
(2005) J Biol Chem 280: 31768-75 - LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
Kaufman JM, Amann JM, Park K, Arasada RR, Li H, Shyr Y, Carbone DP
(2014) J Thorac Oncol 9: 794-804 - Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Sekhar KR, Rachakonda G, Freeman ML
(2010) Toxicol Appl Pharmacol 244: 21-6 - Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.
Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML
(2008) Chem Res Toxicol 21: 705-10 - Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.
Hong F, Freeman ML, Liebler DC
(2005) Chem Res Toxicol 18: 1917-26 - NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
Nlandu-Khodo S, Dissard R, Hasler U, Schäfer M, Pircher H, Jansen-Durr P, Krause KH, Martin PY, de Seigneux S
(2016) Sci Rep 6: 38598 - Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas.
Stacy DR, Ely K, Massion PP, Yarbrough WG, Hallahan DE, Sekhar KR, Freeman ML
(2006) Head Neck 28: 813-8
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