Checkpoint signaling from a single DNA interstrand crosslink. Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J (2009) Mol Cell 35: 704-15 Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ (2000) Genes Dev 14: 1448-59 Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress. Liu Y, Bertram CC, Shi Q, Zinkel SS (2011) Cell Death Differ 18: 841-52 The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice. Biswas S, Shi Q, Wernick A, Aiello A, Zinkel SS (2013) Cell Death Differ 20: 869-77 Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN (2014) Oncotarget 5: 5637-50 The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA (2007) J Cell Sci 120: 3565-77 Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. Chen Z, Xiao Z, Chen J, Ng SC, Sowin T, Sham H, Rosenberg S, Fesik S, Zhang H (2003) Mol Cancer Ther 2: 543-8 Rapid activation of ATR by ionizing radiation requires ATM and Mre11. Myers JS, Cortez D (2006) J Biol Chem 281: 9346-50 Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H (2003) J Biol Chem 278: 21767-73 ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Ball HL, Myers JS, Cortez D (2005) Mol Biol Cell 16: 2372-81 The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Den Haese GJ, Walworth N, Carr AM, Gould KL (1995) Mol Biol Cell 6: 371-85 Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase. Luzwick JW, Nam EA, Zhao R, Cortez D (2014) PLoS One 9: e99397
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