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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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Connections to Chemical and Drug Induced Liver Injury are shown below. Double-click or tap a node for more information.
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Publications
- Isolated elevation of alkaline phosphatase level associated with rosiglitazone.
Hachey DM, O'Neil MP, Force RW
(2000) Ann Intern Med 133: 752 - Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.
Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T
(2010) Gastroenterology 139: 987-98 - Tetracycline-induced bile duct paucity and prolonged cholestasis.
Hunt CM, Washington K
(1994) Gastroenterology 107: 1844-7 - Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase.
Gomez-Santos L, Luka Z, Wagner C, Fernandez-Alvarez S, Lu SC, Mato JM, Martinez-Chantar ML, Beraza N
(2012) Hepatology 56: 747-59 - The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.
Fontana RJ, Cirulli ET, Gu J, Kleiner D, Ostrov D, Phillips E, Schutte R, Barnhart H, Chalasani N, Watkins PB, Hoofnagle JH
(2018) J Hepatol 69: 1317-1325 - Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity.
Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebeiro P, George AL, Kim RB, Haines JL, Sterling TR
(2006) Clin Infect Dis 43: 779-82 - Hydroxyurea-induced hepatitis in human immunodeficiency virus-positive patients.
Weissman SB, Sinclair GI, Green CL, Fissell WH
(1999) Clin Infect Dis 29: 223-4 - Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration.
Haas DW, Bartlett JA, Andersen JW, Sanne I, Wilkinson GR, Hinkle J, Rousseau F, Ingram CD, Shaw A, Lederman MM, Kim RB, Adult AIDS Clinical Trials Group
(2006) Clin Infect Dis 43: 783-6 - Importance of functional EGF receptors in recovery from acute nephrotoxic injury.
Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC
(2003) J Am Soc Nephrol 14: 3147-54 - Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury.
Williams AT, Burk RF
(1990) Semin Liver Dis 10: 279-84 - Effect of combination therapy with cyclosporine and methotrexate on liver function test results in rheumatoid arthritis.
Stein CM, Brooks RH, Pincus T
(1997) Arthritis Rheum 40: 1721-3 - The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.
Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D
(2011) Clin Pharmacol Ther 89: 784-5 - Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.
Nicoletti P, Barrett S, McEvoy L, Daly AK, Aithal G, Lucena MI, Andrade RJ, Wadelius M, Hallberg P, Stephens C, Bjornsson ES, Friedmann P, Kainu K, Laitinen T, Marson A, Molokhia M, Phillips E, Pichler W, Romano A, Shear N, Sills G, Tanno LK, Swale A, Floratos A, Shen Y, Nelson MR, Watkins PB, Daly MJ, Morris AP, Alfirevic A, Pirmohamed M
(2019) Clin Pharmacol Ther 106: 1028-1036 - HLA-B*5701 and flucloxacillin associated drug-induced liver disease.
Phillips EJ, Mallal SA
(2013) AIDS 27: 491-2 - Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Ksontini R, Colagiovanni DB, Josephs MD, Edwards CK, Tannahill CL, Solorzano CC, Norman J, Denham W, Clare-Salzler M, MacKay SL, Moldawer LL
(1998) J Immunol 160: 4082-9 - Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Solorzano CC, Ksontini R, Pruitt JH, Hess PJ, Edwards PD, Kaibara A, Abouhamze A, Auffenberg T, Galardy RE, Vauthey JN, Copeland EM, Edwards CK, Lauwers GY, Clare-Salzler M, MacKay SL, Moldawer LL, Lazarus DD
(1997) J Immunol 158: 414-9 - Increased reporting of fatal hepatitis associated with immune checkpoint inhibitors.
Vozy A, De Martin E, Johnson DB, Lebrun-Vignes B, Moslehi JJ, Salem JE
(2019) Eur J Cancer 123: 112-115 - Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.
Phillips E, Bartlett JA, Sanne I, Lederman MM, Hinkle J, Rousseau F, Dunn D, Pavlos R, James I, Mallal SA, Haas DW
(2013) J Acquir Immune Defic Syndr 62: e55-7 - Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats.
Pannala VR, Vinnakota KC, Rawls KD, Estes SK, O'Brien TP, Printz RL, Papin JA, Reifman J, Shiota M, Young JD, Wallqvist A
(2019) Toxicol Appl Pharmacol 372: 19-32 - Inhibitory effects of suramin on a human renal cell carcinoma line, causing nephrogenic hepatic dysfunction.
Chang SY, Yu DS, Sherwood ER, Kozlowski JM, Lee C
(1992) J Urol 147: 1147-50 - Applying mechanisms of chemical toxicity to predict drug safety.
Guengerich FP, MacDonald JS
(2007) Chem Res Toxicol 20: 344-69 - Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.
Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE
(2015) Am J Physiol Gastrointest Liver Physiol 308: G364-77 - Mechanism of isoniazid-induced hepatotoxicity: then and now.
Metushi I, Uetrecht J, Phillips E
(2016) Br J Clin Pharmacol 81: 1030-6 - Automatic identification of methotrexate-induced liver toxicity in patients with rheumatoid arthritis from the electronic medical record.
Lin C, Karlson EW, Dligach D, Ramirez MP, Miller TA, Mo H, Braggs NS, Cagan A, Gainer V, Denny JC, Savova GK
(2015) J Am Med Inform Assoc 22: e151-61 - Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.
Josephs MD, Bahjat FR, Fukuzuka K, Ksontini R, Solorzano CC, Edwards CK, Tannahill CL, MacKay SL, Copeland EM, Moldawer LL
(2000) Am J Physiol Regul Integr Comp Physiol 278: R1196-201 - Massive intrahepatic hemorrhage following routine liver biopsy in a patient with rheumatoid arthritis treated with methotrexate.
Cash JM, Swain M, Di Bisceglie AM, Wilder RL, Crofford LJ
(1992) J Rheumatol 19: 1466-8 - Three months of weekly rifapentine plus isoniazid is less hepatotoxic than nine months of daily isoniazid for LTBI.
Bliven-Sizemore EE, Sterling TR, Shang N, Benator D, Schwartzman K, Reves R, Drobeniuc J, Bock N, Villarino ME, TB Trials Consortium
(2015) Int J Tuberc Lung Dis 19: 1039-44, i-v - Rapid onset of risperidone-induced hepatotoxicity.
Phillips EJ, Liu BA, Knowles SR
(1998) Ann Pharmacother 32: 843 - Mechanisms of drug toxicity and relevance to pharmaceutical development.
Guengerich FP
(2011) Drug Metab Pharmacokinet 26: 3-14 - Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn.
Anilakumar KR, Nagaraj NS, Santhanam K
(2007) Indian J Exp Biol 45: 450-4
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