HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects. Han Y, Heuermann RJ, Lyman KA, Fisher D, Ismail QA, Chetkovich DM (2017) Mol Psychiatry 22: 458-465 Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN (2012) Proc Natl Acad Sci U S A 109: 7899-904 Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels. Zobeiri M, Chaudhary R, Datunashvili M, Heuermann RJ, Lüttjohann A, Narayanan V, Balfanz S, Meuth P, Chetkovich DM, Pape HC, Baumann A, van Luijtelaar G, Budde T (2018) Brain Struct Funct 223: 1537-1564 Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Lewis AS, Vaidya SP, Blaiss CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, Van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM (2011) J Neurosci 31: 7424-40 TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels. Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM (2012) J Neurosci 32: 14835-48 Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM (2009) J Neurosci 29: 6250-65 Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors. Nam YJ, Lubczyk C, Bhakta M, Zang T, Fernandez-Perez A, McAnally J, Bassel-Duby R, Olson EN, Munshi NV (2014) Development 141: 4267-78 Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA (2014) FASEB J 28: 2177-90 Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Chung WK, Shin M, Jaramillo TC, Leibel RL, LeDuc CA, Fischer SG, Tzilianos E, Gheith AA, Lewis AS, Chetkovich DM (2009) Neurobiol Dis 33: 499-508 Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy. Shin M, Brager D, Jaramillo TC, Johnston D, Chetkovich DM (2008) Neurobiol Dis 32: 26-36 Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C (2018) Mol Neurobiol 55: 7500-7511 Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram TZ (2010) J Biol Chem 285: 14724-36 Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons. Shin M, Chetkovich DM (2007) J Biol Chem 282: 33168-80 Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. Lyman KA, Han Y, Heuermann RJ, Cheng X, Kurz JE, Lyman RE, Van Veldhoven PP, Chetkovich DM (2017) J Biol Chem 292: 17718-17730 Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM (2011) J Biol Chem 286: 20823-34 Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C (2012) J Biol Chem 287: 17656-61 Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder. Lyman KA, Han Y, Chetkovich DM (2017) Expert Opin Ther Targets 21: 235-237 HCN channels in the hippocampus regulate active coping behavior. Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM (2018) J Neurochem 146: 753-766 Early treatment suppresses the development of spike-wave epilepsy in a rat model. Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR (2008) Epilepsia 49: 400-9 Increased seizure severity and seizure-related death in mice lacking HCN1 channels. Santoro B, Lee JY, Englot DJ, Gildersleeve S, Piskorowski RA, Siegelbaum SA, Winawer MR, Blumenfeld H (2010) Epilepsia 51: 1624-7 Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA (2012) PLoS One 7: e32181 TRIP8b is required for maximal expression of HCN1 in the mouse retina. Pan Y, Bhattarai S, Modestou M, Drack AV, Chetkovich DM, Baker SA (2014) PLoS One 9: e85850 Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice. Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM (2018) PLoS One 13: e0193012 Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. Dougherty KA, Nicholson DA, Diaz L, Buss EW, Neuman KM, Chetkovich DM, Johnston D (2013) J Neurophysiol 109: 1940-53 Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b. Brager DH, Lewis AS, Chetkovich DM, Johnston D (2013) J Neurophysiol 110: 2350-7 Evaluation of HCN2 abnormalities as a cause of juvenile audiogenic seizures in Black Swiss mice. Shin M, Simkin D, Suyeoka GM, Chetkovich DM (2006) Brain Res 1083: 14-20 Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Han Y, Lyman K, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM (2015) J Biomol Screen 20: 1124-31
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