HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects. Han Y, Heuermann RJ, Lyman KA, Fisher D, Ismail QA, Chetkovich DM (2017) Mol Psychiatry 22: 458-465 An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision. Khurana S, Liu Z, Lewis AS, Rosa K, Chetkovich D, Golding NL (2012) J Neurosci 32: 2814-23 Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM (2009) J Neurosci 29: 6250-65 Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Lewis AS, Vaidya SP, Blaiss CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, Van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM (2011) J Neurosci 31: 7424-40 TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels. Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM (2012) J Neurosci 32: 14835-48 Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy. Shin M, Brager D, Jaramillo TC, Johnston D, Chetkovich DM (2008) Neurobiol Dis 32: 26-36 Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains. Kanyshkova T, Meuth P, Bista P, Liu Z, Ehling P, Caputi L, Doengi M, Chetkovich DM, Pape HC, Budde T (2012) Neurobiol Dis 45: 450-61 Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Chung WK, Shin M, Jaramillo TC, Leibel RL, LeDuc CA, Fischer SG, Tzilianos E, Gheith AA, Lewis AS, Chetkovich DM (2009) Neurobiol Dis 33: 499-508 Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram TZ (2010) J Biol Chem 285: 14724-36 Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C (2012) J Biol Chem 287: 17656-61 Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM (2011) J Biol Chem 286: 20823-34 Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons. Shin M, Chetkovich DM (2007) J Biol Chem 282: 33168-80 Increased seizure severity and seizure-related death in mice lacking HCN1 channels. Santoro B, Lee JY, Englot DJ, Gildersleeve S, Piskorowski RA, Siegelbaum SA, Winawer MR, Blumenfeld H (2010) Epilepsia 51: 1624-7 Early treatment suppresses the development of spike-wave epilepsy in a rat model. Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR (2008) Epilepsia 49: 400-9 HCN channels in behavior and neurological disease: too hyper or not active enough? Lewis AS, Chetkovich DM (2011) Mol Cell Neurosci 46: 357-67 Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA (2012) PLoS One 7: e32181 Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. Dougherty KA, Nicholson DA, Diaz L, Buss EW, Neuman KM, Chetkovich DM, Johnston D (2013) J Neurophysiol 109: 1940-53
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