Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY (2008) Nature 452: 713-8 Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes. Bowman AB, Lam YC, Jafar-Nejad P, Chen HK, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY (2007) Nat Genet 39: 373-9 ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY (2006) Cell 127: 1335-47 ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY (2011) Dev Cell 21: 746-57
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.