ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL (2000) Mol Cell 6: 1355-64 Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy. Plate L, Wiseman RL (2017) Trends Cell Biol 27: 722-737 Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC (2019) Nat Commun 10: 187 Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL (2014) Proc Natl Acad Sci U S A 111: 13046-51
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.