HIV: Antiviral action countered by Nef. Aiken C (2015) Nature 526: 202-3 The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D (1997) Immunity 6: 67-77 HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I (2006) J Am Soc Nephrol 17: 2832-43 Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes. Almeida CA, Bronke C, Roberts SG, McKinnon E, Keane NM, Chopra A, Kadie C, Carlson J, Haas DW, Riddler SA, Haubrich R, Heckerman D, Mallal S, John M (2011) J Immunol 187: 2502-13 Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. Tobiume M, Lineberger JE, Lundquist CA, Miller MD, Aiken C (2003) J Virol 77: 10645-50 Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex. Forshey BM, Aiken C (2003) J Virol 77: 4409-14 Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C (2002) J Virol 76: 4625-33 Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope. Zhou J, Aiken C (2001) J Virol 75: 5851-9 Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. Chazal N, Singer G, Aiken C, Hammarskjöld ML, Rekosh D (2001) J Virol 75: 4014-8 Association of Nef with the human immunodeficiency virus type 1 core. Kotov A, Zhou J, Flicker P, Aiken C (1999) J Virol 73: 8824-30 Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. Aiken C (1997) J Virol 71: 5871-7 Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. Qi M, Aiken C (2007) J Virol 81: 1534-6 Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication. Lundquist CA, Zhou J, Aiken C (2004) J Virol 78: 6287-96 HIV-1 Nef mediates post-translational down-regulation and redistribution of the mannose receptor. Vigerust DJ, Egan BS, Shepherd VL (2005) J Leukoc Biol 77: 522-34 HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal S (2009) PLoS One 4: e6687 Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity. Aiken C (1998) Virology 248: 139-47 Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Aiken C, Krause L, Chen YL, Trono D (1996) Virology 217: 293-300 Nef enhances HIV-1 infectivity via association with the virus assembly complex. Qi M, Aiken C (2008) Virology 373: 287-97
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