HIV: Antiviral action countered by Nef. Aiken C (2015) Nature 526: 202-3 The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D (1997) Immunity 6: 67-77 HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I (2006) J Am Soc Nephrol 17: 2832-43 Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes. Almeida CA, Bronke C, Roberts SG, McKinnon E, Keane NM, Chopra A, Kadie C, Carlson J, Haas DW, Riddler SA, Haubrich R, Heckerman D, Mallal S, John M (2011) J Immunol 187: 2502-13 Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex. Forshey BM, Aiken C (2003) J Virol 77: 4409-14 Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C (2002) J Virol 76: 4625-33 Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope. Zhou J, Aiken C (2001) J Virol 75: 5851-9 Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. Chazal N, Singer G, Aiken C, Hammarskjöld ML, Rekosh D (2001) J Virol 75: 4014-8 Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. Aiken C (1997) J Virol 71: 5871-7 Association of Nef with the human immunodeficiency virus type 1 core. Kotov A, Zhou J, Flicker P, Aiken C (1999) J Virol 73: 8824-30 Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. Qi M, Aiken C (2007) J Virol 81: 1534-6 Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication. Lundquist CA, Zhou J, Aiken C (2004) J Virol 78: 6287-96 Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. Tobiume M, Lineberger JE, Lundquist CA, Miller MD, Aiken C (2003) J Virol 77: 10645-50 HIV-1 Nef mediates post-translational down-regulation and redistribution of the mannose receptor. Vigerust DJ, Egan BS, Shepherd VL (2005) J Leukoc Biol 77: 522-34 Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Aiken C, Krause L, Chen YL, Trono D (1996) Virology 217: 293-300 Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity. Aiken C (1998) Virology 248: 139-47 Nef enhances HIV-1 infectivity via association with the virus assembly complex. Qi M, Aiken C (2008) Virology 373: 287-97
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