Obesity-associated variants within FTO form long-range functional connections with IRX3. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA (2014) Nature 507: 371-5 Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Verma R, Aravind L, Oania R, McDonald WH, Yates JR, Koonin EV, Deshaies RJ (2002) Science 298: 611-5 Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Singer WD, Brown HA, Sternweis PC (1997) Annu Rev Biochem 66: 475-509 Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB (2004) Nat Med 10: 268-74 SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC (2013) Mol Cell 50: 686-98 17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. Yanase T, Simpson ER, Waterman MR (1991) Endocr Rev 12: 91-108 The human invariant chain is the core protein of the human class II-associated proteoglycan. Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD (1986) J Exp Med 164: 1422-39 Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. O'Maille PE, Malone A, Dellas N, Andes Hess B, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel JP (2008) Nat Chem Biol 4: 617-23 The Response of Acinetobacter baumannii to Zinc Starvation. Nairn BL, Lonergan ZR, Wang J, Braymer JJ, Zhang Y, Calcutt MW, Lisher JP, Gilston BA, Chazin WJ, de Crécy-Lagard V, Giedroc DP, Skaar EP (2016) Cell Host Microbe 19: 826-36 Dyskerin, tRNA genes, and condensin tether pericentric chromatin to the spindle axis in mitosis. Snider CE, Stephens AD, Kirkland JG, Hamdani O, Kamakaka RT, Bloom K (2014) J Cell Biol 207: 189-99 Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks. Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ (2018) Proc Natl Acad Sci U S A 115: 9228-9233 Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ (2015) J Neurosci 35: 15326-38 APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts. Hong J, Chen Z, Peng D, Zaika A, Revetta F, Washington MK, Belkhiri A, El-Rifai W (2016) Oncotarget 7: 16688-702 Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene. Yanase T, Sanders D, Shibata A, Matsui N, Simpson ER, Waterman MR (1990) J Clin Endocrinol Metab 70: 1325-9 Compound heterozygous mutations (Arg 239----stop, Pro 342----Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. Ahlgren R, Yanase T, Simpson ER, Winter JS, Waterman MR (1992) J Clin Endocrinol Metab 74: 667-72 NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity. Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS (2013) J Immunol 190: 4786-94 Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. De Silva AD, Park JJ, Matsuki N, Stanic AK, Brutkiewicz RR, Medof ME, Joyce S (2002) J Immunol 168: 723-33 Genetic variation in the urea cycle: a model resource for investigating key candidate genes for common diseases. Mitchell S, Ellingson C, Coyne T, Hall L, Neill M, Christian N, Higham C, Dobrowolski SF, Tuchman M, Summar M, Urea Cycle Disorder Consortium (2009) Hum Mutat 30: 56-60 Clustering of two genes putatively involved in cyanate detoxification evolved recently and independently in multiple fungal lineages. Elmore MH, McGary KL, Wisecaver JH, Slot JC, Geiser DM, Sink S, O'Donnell K, Rokas A (2015) Genome Biol Evol 7: 789-800 Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiency. Kagimoto M, Winter JS, Kagimoto K, Simpson ER, Waterman MR (1988) Mol Endocrinol 2: 564-70 Deletion within the CYP17 gene together with insertion of foreign DNA is the cause of combined complete 17 alpha-hydroxylase/17,20-lyase deficiency in an Italian patient. Biason A, Mantero F, Scaroni C, Simpson ER, Waterman MR (1991) Mol Endocrinol 5: 2037-45 Dexamethasone inhibits corticotropin-induced accumulation of CYP11A and CYP17 messenger RNAs in bovine adrenocortical cells. Trzeciak WH, LeHoux JG, Waterman MR, Simpson ER (1993) Mol Endocrinol 7: 206-13 Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture. McAllister JM, Kerin JF, Trant JM, Estabrook RW, Mason JI, Waterman MR, Simpson ER (1989) Endocrinology 125: 1959-66 Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities. Jenkins CM, Waterman MR (1994) J Biol Chem 269: 27401-8 Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter. Stafford JM, Wilkinson JC, Beechem JM, Granner DK (2001) J Biol Chem 276: 39885-91 Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. Schneider C, Tallman KA, Porter NA, Brash AR (2001) J Biol Chem 276: 20831-8 Deletion of a phenylalanine in the N-terminal region of human cytochrome P-450(17 alpha) results in partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. Yanase T, Kagimoto M, Suzuki S, Hashiba K, Simpson ER, Waterman MR (1989) J Biol Chem 264: 18076-82 Identification of a common molecular basis for combined 17 alpha-hydroxylase/17,20-lyase deficiency in two Mennonite families. Kagimoto K, Waterman MR, Kagimoto M, Ferreira P, Simpson ER, Winter JS (1989) Hum Genet 82: 285-6 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N (2002) J Lipid Res 43: 1220-35 Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. Smith CE, Follis JL, Nettleton JA, Foy M, Wu JH, Ma Y, Tanaka T, Manichakul AW, Wu H, Chu AY, Steffen LM, Fornage M, Mozaffarian D, Kabagambe EK, Ferruci L, Chen YD, Rich SS, Djoussé L, Ridker PM, Tang W, McKnight B, Tsai MY, Bandinelli S, Rotter JI, Hu FB, Chasman DI, Psaty BM, Arnett DK, King IB, Sun Q, Wang L, Lumley T, Chiuve SE, Siscovick DS, Ordovás JM, Lemaitre RN (2015) Mol Nutr Food Res 59: 1373-83 Growth phase regulation of flaA expression in Helicobacter pylori is luxS dependent. Loh JT, Forsyth MH, Cover TL (2004) Infect Immun 72: 5506-10 Intercellular communication in Helicobacter pylori: luxS is essential for the production of an extracellular signaling molecule. Forsyth MH, Cover TL (2000) Infect Immun 68: 3193-9 Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a stop codon in the N-terminal region of 17 alpha-hydroxylase cytochrome P-450. Yanase T, Kagimoto M, Matsui N, Simpson ER, Waterman MR (1988) Mol Cell Endocrinol 59: 249-53 cAMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture. Lauber ME, Kagawa N, Waterman MR, Simpson ER (1993) Mol Cell Endocrinol 93: 227-33 The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung. Paulson NB, Gilbertsen AJ, Dalluge JJ, Welchlin CW, Hughes J, Han W, Blackwell TS, Laguna TA, Williams BJ (2014) PLoS One 9: e111441 Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection. Liu M, Blinn C, McLeod SM, Wiseman JW, Newman JV, Fisher SL, Walkup GK (2014) PLoS One 9: e90382 Quantitative effect of luxS gene inactivation on the fitness of Helicobacter pylori. Lee WK, Ogura K, Loh JT, Cover TL, Berg DE (2006) Appl Environ Microbiol 72: 6615-22 Binding of tenascin-X to decorin. Elefteriou F, Exposito JY, Garrone R, Lethias C (2001) FEBS Lett 495: 44-7 Concerted, highly asynchronous, enzyme-catalyzed [4 + 2] cycloaddition in the biosynthesis of spinosyn A; computational evidence. Hess BA, Smentek L (2012) Org Biomol Chem 10: 7503-9 Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis. Williams D, Fingleton B (2019) Clin Exp Metastasis 36: 211-224
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.