Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function. Komalavilas P, Luo W, Guth CM, Jolayemi O, Bartelson RI, Cheung-Flynn J, Brophy CM (2017) PLoS One 12: e0188069 Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways. Cheung-Flynn J, Alvis BD, Hocking KM, Guth CM, Luo W, McCallister R, Chadalavada K, Polcz M, Komalavilas P, Brophy CM (2019) PLoS One 14: e0220893 Mechanosensitive Ion Channels: TRPV4 and P2X7 in Disseminating Cancer Cells. Hope JM, Greenlee JD, King MR (2018) Cancer J 24: 84-92 Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury. Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J (2016) J Vasc Surg 64: 210-8 Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia. Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J (2016) J Vasc Surg 64: 471-478 P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis. Luo W, Feldman D, McCallister R, Brophy C, Cheung-Flynn J (2017) Purinergic Signal 13: 579-590 Blocking the P2X7 receptor improves outcomes after axonal fusion. Rodriguez-Feo CL, Sexton KW, Boyer RB, Pollins AC, Cardwell NL, Nanney LB, Shack RB, Mikesh MA, McGill CH, Driscoll CW, Bittner GD, Thayer WP (2013) J Surg Res 184: 705-13 Adenosine triphosphate as a molecular mediator of the vascular response to injury. Guth CM, Luo W, Jolayemi O, Chadalavada KS, Komalavilas P, Cheung-Flynn J, Brophy CM (2017) J Surg Res 216: 80-86
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.