Titin determines the Frank-Starling relation in early diastole. Helmes M, Lim CC, Liao R, Bharti A, Cui L, Sawyer DB (2003) J Gen Physiol 121: 97-110 Modulation of cardiac function: titin springs into action. Lim CC, Sawyer DB (2005) J Gen Physiol 125: 249-52 Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. Lim CC, Zuppinger C, Guo X, Kuster GM, Helmes M, Eppenberger HM, Suter TM, Liao R, Sawyer DB (2004) J Biol Chem 279: 8290-9 Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes. Pentassuglia L, Graf M, Lane H, Kuramochi Y, Cote G, Timolati F, Sawyer DB, Zuppinger C, Suter TM (2009) Exp Cell Res 315: 1302-12 Upstream open reading frame in 5'-untranslated region reduces titin mRNA translational efficiency. Cadar AG, Zhong L, Lin A, Valenzuela MO, Lim CC (2014) Biochem Biophys Res Commun 453: 185-91
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