Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Kuss SK, Best GT, Etheredge CA, Pruijssers AJ, Frierson JM, Hooper LV, Dermody TS, Pfeiffer JK (2011) Science 334: 249-52 Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. Johansson C, Wetzel JD, He J, Mikacenic C, Dermody TS, Kelsall BL (2007) J Exp Med 204: 1349-58 Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. Fleeton MN, Contractor N, Leon F, Wetzel JD, Dermody TS, Kelsall BL (2004) J Exp Med 200: 235-45 Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. Barton ES, Youree BE, Ebert DH, Forrest JC, Connolly JL, Valyi-Nagy T, Washington K, Wetzel JD, Dermody TS (2003) J Clin Invest 111: 1823-33 Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells. Rubin DH, Wetzel JD, Williams WV, Cohen JA, Dworkin C, Dermody TS (1992) J Clin Invest 90: 2536-42 Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Boehme KW, Guglielmi KM, Dermody TS (2009) Proc Natl Acad Sci U S A 106: 19986-91 Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. Tai JH, Williams JV, Edwards KM, Wright PF, Crowe JE, Dermody TS (2005) J Infect Dis 191: 1221-4 Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. Excoffon KJ, Guglielmi KM, Wetzel JD, Gansemer ND, Campbell JA, Dermody TS, Zabner J (2008) J Infect Dis 197: 1189-97 Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O'Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS (2004) J Infect Dis 189: 1664-75 JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. Danthi P, Hansberger MW, Campbell JA, Forrest JC, Dermody TS (2006) J Virol 80: 1261-70 Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. O'Donnell SM, Holm GH, Pierce JM, Tian B, Watson MJ, Chari RS, Ballard DW, Brasier AR, Dermody TS (2006) J Virol 80: 1077-86 Beta1 integrin mediates internalization of mammalian reovirus. Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM, Nemerow GR, Bergelson JM, Dermody TS (2006) J Virol 80: 2760-70 Gene-specific inhibition of reovirus replication by RNA interference. Kobayashi T, Chappell JD, Danthi P, Dermody TS (2006) J Virol 80: 9053-63 Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. Danthi P, Kobayashi T, Holm GH, Hansberger MW, Abel TW, Dermody TS (2008) J Virol 82: 161-72 Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9. Zurney J, Kobayashi T, Holm GH, Dermody TS, Sherry B (2009) J Virol 83: 2178-87 The reovirus S4 gene 3' nontranslated region contains a translational operator sequence. Mochow-Grundy M, Dermody TS (2001) J Virol 75: 6517-26 Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. Rodgers SE, Barton ES, Oberhaus SM, Pike B, Gibson CA, Tyler KL, Dermody TS (1997) J Virol 71: 2540-6 Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL (1997) J Virol 71: 2100-6 Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1. Chappell JD, Gunn VL, Wetzel JD, Baer GS, Dermody TS (1997) J Virol 71: 1834-41 Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant. Rodgers SE, Connolly JL, Chappell JD, Dermody TS (1998) J Virol 72: 8597-604 Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. Chappell JD, Duong JL, Wright BW, Dermody TS (2000) J Virol 74: 8472-9 Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2). Poggioli GJ, Dermody TS, Tyler KL (2001) J Virol 75: 7429-34 Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. Baer GS, Dermody TS (1997) J Virol 71: 4921-8 Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. Wetzel JD, Barton ES, Chappell JD, Baer GS, Mochow-Grundy M, Rodgers SE, Shyr Y, Powers AC, Thomas JW, Dermody TS (2006) J Virol 80: 3078-82 The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. Boehme KW, Frierson JM, Konopka JL, Kobayashi T, Dermody TS (2011) J Virol 85: 11781-90 A single-amino-acid polymorphism in reovirus protein μ2 determines repression of interferon signaling and modulates myocarditis. Irvin SC, Zurney J, Ooms LS, Chappell JD, Dermody TS, Sherry B (2012) J Virol 86: 2302-11 Utilization of sialylated glycans as coreceptors enhances the neurovirulence of serotype 3 reovirus. Frierson JM, Pruijssers AJ, Konopka JL, Reiter DM, Abel TW, Stehle T, Dermody TS (2012) J Virol 86: 13164-73 Apoptosis induction influences reovirus replication and virulence in newborn mice. Pruijssers AJ, Hengel H, Abel TW, Dermody TS (2013) J Virol 87: 12980-9 Nonstructural protein σ1s mediates reovirus-induced cell cycle arrest and apoptosis. Boehme KW, Hammer K, Tollefson WC, Konopka-Anstadt JL, Kobayashi T, Dermody TS (2013) J Virol 87: 12967-79 A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. Dermody TS, Nibert ML, Bassel-Duby R, Fields BN (1990) J Virol 64: 5173-6 Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. Dermody TS, Nibert ML, Bassel-Duby R, Fields BN (1990) J Virol 64: 4842-50 Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. Nibert ML, Chappell JD, Dermody TS (1995) J Virol 69: 5057-67 Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. Wetzel JD, Chappell JD, Fogo AB, Dermody TS (1997) J Virol 71: 299-306 Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes. Tyler KL, Squier MK, Brown AL, Pike B, Willis D, Oberhaus SM, Dermody TS, Cohen JJ (1996) J Virol 70: 7984-91 IkappaB kinase subunits alpha and gamma are required for activation of NF-kappaB and induction of apoptosis by mammalian reovirus. Hansberger MW, Campbell JA, Danthi P, Arrate P, Pennington KN, Marcu KB, Ballard DW, Dermody TS (2007) J Virol 81: 1360-71
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.