Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia. Bychkov ER, Gurevich VV, Joyce JN, Benovic JL, Gurevich EV (2008) Neurobiol Aging 29: 379-96 Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder. Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV (2011) Neurobiol Dis 44: 248-58 mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin. Lowe JD, Celver JP, Gurevich VV, Chavkin C (2002) J Biol Chem 277: 15729-35 Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C (2001) J Biol Chem 276: 4894-900 Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, Bychkov E, Gurevich VV, Benovic JL, Gurevich EV (2008) J Neurochem 104: 1622-36 Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation. Ahmed MR, Gurevich VV, Dalby KN, Benovic JL, Gurevich EV (2008) J Pharmacol Exp Ther 325: 276-83 GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain. Ahmed MR, Bychkov E, Li L, Gurevich VV, Gurevich EV (2015) Sci Rep 5: 10920
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.