Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR (2016) Nature 537: 234-238 Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites. Wan X, Thomas JW, Unanue ER (2016) J Exp Med 213: 967-78 Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. Curotto de Lafaille MA, Muriglan S, Sunshine MJ, Lei Y, Kutchukhidze N, Furtado GC, Wensky AK, Olivares-Villagómez D, Lafaille JJ (2001) J Exp Med 194: 1349-59 Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC (1996) J Exp Med 183: 2271-82 Hypoxia-inducible factors in CD4 T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity. Cho SH, Raybuck AL, Blagih J, Kemboi E, Haase VH, Jones RG, Boothby MR (2019) Proc Natl Acad Sci U S A 116: 8975-8984 Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Pao W, Wen L, Smith AL, Gulbranson-Judge A, Zheng B, Kelsoe G, MacLennan IC, Owen MJ, Hayday AC (1996) Curr Biol 6: 1317-25 Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups. Freathy RM, Hayes MG, Urbanek M, Lowe LP, Lee H, Ackerman C, Frayling TM, Cox NJ, Dunger DB, Dyer AR, Hattersley AT, Metzger BE, Lowe WL, HAPO Study Cooperative Research Group (2010) Diabetes 59: 2682-9 Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function. Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD (2000) J Immunol 165: 5418-27 Microarray analysis of Lyn-deficient B cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center. Mirnics ZK, Caudell E, Gao Y, Kuwahara K, Sakaguchi N, Kurosaki T, Burnside J, Mirnics K, Corey SJ (2004) J Immunol 172: 4133-41 Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes. Kendall PL, Yu G, Woodward EJ, Thomas JW (2007) J Immunol 178: 5643-51 Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells. Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM (2015) J Immunol 195: 1364-1367 B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity. Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR (2018) J Immunol 200: 2627-2639 Germinal center formation in mice lacking alpha beta T cells. Dianda L, Gulbranson-Judge A, Pao W, Hayday AC, MacLennan IC, Owen MJ (1996) Eur J Immunol 26: 1603-7 GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel. Denton J, Nehrke K, Yin X, Morrison R, Strange K (2005) J Gen Physiol 125: 113-25 BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM (2012) PLoS One 7: e41343 Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM (2019) Cytometry A 95: 442-449 Regulatory myeloid cells: an underexplored continent in B-cell lymphomas. Roussel M, Irish JM, Menard C, Lhomme F, Tarte K, Fest T (2017) Cancer Immunol Immunother 66: 1103-1111 Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas. Roussel M, Lhomme F, Roe CE, Bartkowiak T, Gravelle P, Laurent C, Fest T, Irish JM (2020) Cancer Immunol Immunother 69: 407-420 Detection and cellular localization of 12R-lipoxygenase in human tonsils. Schneider C, Keeney DS, Boeglin WE, Brash AR (2001) Arch Biochem Biophys 386: 268-74 Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations. Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2017) Cytometry B Clin Cytom 92: 79-87
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