HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D (2019) Cell 176: 144-153.e13 Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions. Sabourin M, Osheroff N (2000) Nucleic Acids Res 28: 1947-54 Apurinic sites are position-specific topoisomerase II poisons. Kingma PS, Osheroff N (1997) J Biol Chem 272: 1148-55 Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η. Patra A, Zhang Q, Lei L, Su Y, Egli M, Guengerich FP (2015) J Biol Chem 290: 8028-38 DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison. Cline SD, Jones WR, Stone MP, Osheroff N (1999) Biochemistry 38: 15500-7
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