Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis. Xu S, Mueser TC, Marnett LJ, Funk MO (2012) Structure 20: 1490-7 Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ (2018) J Biol Chem 293: 3028-3038 Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. Richards KM, Moody JS, Marnett LJ (1999) Biochemistry 38: 16529-38 Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. Moody JS, Marnett LJ (2002) Biochemistry 41: 10297-303
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