Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis. Nørgaard P, Law B, Joseph H, Page DL, Shyr Y, Mays D, Pietenpol JA, Kohl NE, Oliff A, Coffey RJ, Poulsen HS, Moses HL (1999) Clin Cancer Res 5: 35-42 Mob-1, a Ras target gene, is overexpressed in colorectal cancer. Zhang R, Zhang H, Zhu W, Pardee AB, Coffey RJ, Liang P (1997) Oncogene 14: 1607-10 Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli. Law BK, Norgaard P, Moses HL (2000) J Biol Chem 275: 10796-801 Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. Law BK, Nørgaard P, Gnudi L, Kahn BB, Poulson HS, Moses HL (1999) J Biol Chem 274: 4743-8 Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation. Nørgaard P, Law BK, Plovisson HS, Moses HL (1999) Ann N Y Acad Sci 886: 265-8 Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta. Du J, Jiang B, Coffey RJ, Barnard J (2004) Mol Cancer Res 2: 233-41 Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer. Arteaga CL, Khuri F, Krystal G, Sebti S (2002) Semin Oncol 29: 15-26
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