Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ (2005) Neuron 46: 555-67 Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Song X, Vishnivetskiy SA, Gross OP, Emelianoff K, Mendez A, Chen J, Gurevich EV, Burns ME, Gurevich VV (2009) Curr Biol 19: 700-5 Custom-designed proteins as novel therapeutic tools? The case of arrestins. Gurevich VV, Gurevich EV (2010) Expert Rev Mol Med 12: e13 Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding. Bayburt TH, Vishnivetskiy SA, McLean MA, Morizumi T, Huang CC, Tesmer JJ, Ernst OP, Sligar SG, Gurevich VV (2011) J Biol Chem 286: 1420-8 Regulation of arrestin binding by rhodopsin phosphorylation level. Vishnivetskiy SA, Raman D, Wei J, Kennedy MJ, Hurley JB, Gurevich VV (2007) J Biol Chem 282: 32075-83 Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. Krupnick JG, Gurevich VV, Benovic JL (1997) J Biol Chem 272: 18125-31 The selectivity of visual arrestin for light-activated phosphorhodopsin is controlled by multiple nonredundant mechanisms. Gurevich VV (1998) J Biol Chem 273: 15501-6 Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding. Vishnivetskiy SA, Ostermaier MK, Singhal A, Panneels V, Homan KT, Glukhova A, Sligar SG, Tesmer JJ, Schertler GF, Standfuss J, Gurevich VV (2013) Cell Signal 25: 2155-62 Rhodopsin arginine-135 mutants are phosphorylated by rhodopsin kinase and bind arrestin in the absence of 11-cis-retinal. Shi W, Sports CD, Raman D, Shirakawa S, Osawa S, Weiss ER (1998) Biochemistry 37: 4869-74 Heterologous expression and reconstitution of rhodopsin with rhodopsin kinase and arrestin. Osawa S, Raman D, Weiss ER (2000) Methods Enzymol 315: 411-22
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.