Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M (2010) Angew Chem Int Ed Engl 49: 7481-5 A simple screening approach to reduce B*5701-associated abacavir hypersensitivity on the basis of sequence variation in HIV reverse transcriptase. Chui CK, Brumme ZL, Brumme CJ, Yip B, Phillips EJ, Montaner JS, Harrigan PR (2007) Clin Infect Dis 44: 1503-8 Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase. Choi JY, Guengerich FP (2004) J Biol Chem 279: 19217-29 Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase. Zang H, Harris TM, Guengerich FP (2005) J Biol Chem 280: 1165-78 Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. Eoff RL, Angel KC, Egli M, Guengerich FP (2007) J Biol Chem 282: 13573-84 Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase. Zang H, Harris TM, Guengerich FP (2005) Chem Res Toxicol 18: 389-400 Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Furge LL, Guengerich FP (1997) Biochemistry 36: 6475-87 Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex. Furge LL, Guengerich FP (1999) Biochemistry 38: 4818-25 Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. Einolf HJ, Schnetz-Boutaud N, Guengerich FP (1998) Biochemistry 37: 13300-12 Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. Woodside AM, Guengerich FP (2002) Biochemistry 41: 1039-50 Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. Woodside AM, Guengerich FP (2002) Biochemistry 41: 1027-38
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.