LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J (2013) Nature 499: 306-11 A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Palmer GM, Tiran Z, Zhou Z, Capozzi ME, Park W, Coletta C, Pyriochou A, Kliger Y, Levy O, Borukhov I, Dewhirst MW, Rotman G, Penn JS, Papapetropoulos A (2012) Br J Pharmacol 165: 1891-1903 Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV (2006) Am J Pathol 168: 1722-36 Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Morales-Tirado , Yates CR (2017) Mol Pharmacol 91: 1-13 A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis. Zhao T, Wang D, Cheranov SY, Karpurapu M, Chava KR, Kundumani-Sridharan V, Johnson DA, Penn JS, Rao GN (2009) J Lipid Res 50: 521-533 Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1. Shafiee A, Penn JS, Krutzsch HC, Inman JK, Roberts DD, Blake DA (2000) Invest Ophthalmol Vis Sci 41: 2378-88 Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Bullard LE, Qi X, Penn JS (2003) Invest Ophthalmol Vis Sci 44: 1722-31 Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factor. Penn JS, McCollum GW, Barnett JM, Werdich XQ, Koepke KA, Rajaratnam VS (2006) Invest Ophthalmol Vis Sci 47: 405-14 Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction. Michaelides M, Jenkins SA, Brantley MA, Andrews RM, Waseem N, Luong V, Gregory-Evans K, Bhattacharya SS, Fitzke FW, Webster AR (2006) Invest Ophthalmol Vis Sci 47: 3085-97 Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR. Barnett JM, McCollum GW, Fowler JA, Duan JJ, Kay JD, Liu RQ, Bingaman DP, Penn JS (2007) Invest Ophthalmol Vis Sci 48: 907-15 Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Penn JS, Tolman BL, Lowery LA (1993) Invest Ophthalmol Vis Sci 34: 576-85 Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity. Berkowitz BA, Penn JS (1998) Invest Ophthalmol Vis Sci 39: 840-5 15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesis. Bajpai AK, Blaskova E, Pakala SB, Zhao T, Glasgow WC, Penn JS, Johnson DA, Rao GN (2007) Invest Ophthalmol Vis Sci 48: 4930-8 High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity. Berkowitz BA, Roberts R, Penn JS, Gradianu M (2007) Invest Ophthalmol Vis Sci 48: 4733-40 Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization. Majka S, McGuire PG, Das A (2002) Invest Ophthalmol Vis Sci 43: 260-6 The balance between proteinases and inhibitors in a murine model of proliferative retinopathy. Majka S, McGuire P, Colombo S, Das A (2001) Invest Ophthalmol Vis Sci 42: 210-5 In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO). Uddin MI, Jayagopal A, McCollum GW, Yang R, Penn JS (2017) Invest Ophthalmol Vis Sci 58: 3818-3824 The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Penn JS, Rajaratnam VS, Collier RJ, Clark AF (2001) Invest Ophthalmol Vis Sci 42: 283-90 The role of PGE2 receptor EP4 in pathologic ocular angiogenesis. Yanni SE, Barnett JM, Clark ML, Penn JS (2009) Invest Ophthalmol Vis Sci 50: 5479-86 Identification of genes and pathways involved in retinal neovascularization by microarray analysis of two animal models of retinal angiogenesis. Recchia FM, Xu L, Penn JS, Boone B, Dexheimer PJ (2010) Invest Ophthalmol Vis Sci 51: 1098-105 Role of cytosolic phospholipase A(2) in retinal neovascularization. Barnett JM, McCollum GW, Penn JS (2010) Invest Ophthalmol Vis Sci 51: 1136-42 The role of cytochrome P450 epoxygenases in retinal angiogenesis. Capozzi ME, McCollum GW, Penn JS (2014) Invest Ophthalmol Vis Sci 55: 4253-60 Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization. Werdich XQ, Penn JS (2006) Invest Ophthalmol Vis Sci 47: 5047-56 Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy. Capozzi ME, McCollum GW, Savage SR, Penn JS (2013) Invest Ophthalmol Vis Sci 54: 4197-207 The role of the NFAT signaling pathway in retinal neovascularization. Bretz CA, Savage S, Capozzi M, Penn JS (2013) Invest Ophthalmol Vis Sci 54: 7020-7 Endoglin promotes angiogenesis in cell- and animal-based models of retinal neovascularization. Barnett JM, Suarez S, McCollum GW, Penn JS (2014) Invest Ophthalmol Vis Sci 55: 6490-8 Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity. Penn JS, Rajaratnam VS (2003) Invest Ophthalmol Vis Sci 44: 5423-9 The range of PaO2 variation determines the severity of oxygen-induced retinopathy in newborn rats. Penn JS, Henry MM, Wall PT, Tolman BL (1995) Invest Ophthalmol Vis Sci 36: 2063-70 Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization. Penn JS, Tolman BL, Henry MM (1994) Invest Ophthalmol Vis Sci 35: 3429-35 Inhibition of retinal neovascularization by soluble EphA2 receptor. Chen J, Hicks D, Brantley-Sieders D, Cheng N, McCollum GW, Qi-Werdich X, Penn J (2006) Exp Eye Res 82: 664-73 Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. McCollum GW, Rajaratnam VS, Bullard LE, Yang R, Penn JS (2004) Exp Eye Res 78: 987-95 The effects of nepafenac and amfenac on retinal angiogenesis. Yanni SE, Clark ML, Yang R, Bingaman DP, Penn JS (2010) Brain Res Bull 81: 310-9 Detection of vascular endothelial growth factor (VEGF) protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina. Robbins SG, Conaway JR, Ford BL, Roberto KA, Penn JS (1997) Growth Factors 14: 229-41 The vitreous protein concentration is increased prior to neovascularization in experimental ROP. Berkowitz BA, Roberto KA, Penn JS (1998) Curr Eye Res 17: 218-21 Fluorescein angiography as a means of assessing retinal vascular pathology in oxygen-exposed newborn rats. Penn JS, Johnson BD (1993) Curr Eye Res 12: 561-70 The development of the rat model of retinopathy of prematurity. Barnett JM, Yanni SE, Penn JS (2010) Doc Ophthalmol 120: 3-12
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