TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N (2006) Nat Med 12: 107-13 Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Salic A, Lee E, Mayer L, Kirschner MW (2000) Mol Cell 5: 523-32 Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD (1996) J Clin Invest 97: 81-91 Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle. Hamilton KS, Gibbons FK, Bracy DP, Lacy DB, Cherrington AD, Wasserman DH (1996) J Clin Invest 98: 125-35 Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. Lee E, Salic A, Kirschner MW (2001) J Cell Biol 154: 983-93 Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. Soutto M, Peng D, Katsha A, Chen Z, Piazuelo MB, Washington MK, Belkhiri A, Correa P, El-Rifai W (2015) Gut 64: 1028-39 LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E (2008) Proc Natl Acad Sci U S A 105: 8032-7 Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood. Sillivan SE, Black YD, Naydenov AV, Vassoler FR, Hanlin RP, Konradi C (2011) Biol Psychiatry 70: 583-92 GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. Rao R, Patel S, Hao C, Woodgett J, Harris R (2010) J Am Soc Nephrol 21: 428-37 Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation. Thotala DK, Hallahan DE, Yazlovitskaya EM (2008) Cancer Res 68: 5859-68 Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation. Yazlovitskaya EM, Edwards E, Thotala D, Fu A, Osusky KL, Whetsell WO, Boone B, Shinohara ET, Hallahan DE (2006) Cancer Res 66: 11179-86 Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium. Tan J, Geng L, Yazlovitskaya EM, Hallahan DE (2006) Cancer Res 66: 2320-7 Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Thotala DK, Hallahan DE, Yazlovitskaya EM (2012) Cell Death Differ 19: 387-96 Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice. Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R (2012) Kidney Int 82: 1000-9 Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Fujimoto Y, Torres TP, Donahue EP, Shiota M (2006) Diabetes 55: 2479-90 Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Coate KC, Kraft G, Irimia JM, Smith MS, Farmer B, Neal DW, Roach PJ, Shiota M, Cherrington AD (2013) Diabetes 62: 392-400 Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. von Wilamowitz-Moellendorff A, Hunter RW, García-Rocha M, Kang L, López-Soldado I, Lantier L, Patel K, Peggie MW, Martínez-Pons C, Voss M, Calbó J, Cohen PT, Wasserman DH, Guinovart JJ, Sakamoto K (2013) Diabetes 62: 4070-82 A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. An Z, Winnick JJ, Moore MC, Farmer B, Smith M, Irimia JM, Roach PJ, Cherrington AD (2012) Diabetes 61: 2433-41 Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Ramnanan CJ, Kraft G, Smith MS, Farmer B, Neal D, Williams PE, Lautz M, Farmer T, Donahue EP, Cherrington AD, Edgerton DS (2013) Diabetes 62: 74-84 Hepatic glucose metabolism in late pregnancy: normal versus high-fat and -fructose diet. Coate KC, Smith MS, Shiota M, Irimia JM, Roach PJ, Farmer B, Williams PE, Moore MC (2013) Diabetes 62: 753-61 An approach for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes. Linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM. Gambino V, Menzel S, Trabb JB, Xiang KS, Lindner T, Louït A, Chen E, Mereu LE, Furuta H, Iwasaki N, Kawamura M, Omori Y, Rietzsch H, Schulze J, Schröder HE, Concannon P, Hanis CL, Spielman RS, Yamagata K, Cox NJ, Bell GI (1996) Diabetes 45: 291-4 Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA (2003) Diabetes 52: 1649-54 The aurora kinase A regulates GSK-3beta in gastric cancer cells. Dar AA, Belkhiri A, El-Rifai W (2009) Oncogene 28: 866-75 Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice. Rao R, Hao CM, Redha R, Wasserman DH, McGuinness OP, Breyer MD (2007) Diabetologia 50: 452-60 Interactions between GSK3β and amyloid genes explain variance in amyloid burden. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative (2014) Neurobiol Aging 35: 460-5 Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E (2018) J Cell Sci 131: Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L (2004) J Med Chem 47: 3236-41
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.