Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Newman JH, Phillips JA, Loyd JE (2008) Ann Intern Med 148: 278-83 A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors. Goff LW, Cohen RB, Berlin JD, de Braud FG, Lyshchik A, Noberasco C, Bertolini F, Carpentieri M, Stampino CG, Abbattista A, Wang E, Borghaei H (2016) Clin Cancer Res 22: 2146-54 Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL (2006) Oncogene 25: 3408-23 XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues. Frisch A, Wright CV (1998) Development 125: 431-42 Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor. Kawabata M, Chytil A, Moses HL (1995) J Biol Chem 270: 5625-30 Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility. Ueda Y, Wang S, Dumont N, Yi JY, Koh Y, Arteaga CL (2004) J Biol Chem 279: 24505-13 Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. Yi JY, Shin I, Arteaga CL (2005) J Biol Chem 280: 10870-6 Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha. Kawabata M, Imamura T, Miyazono K, Engel ME, Moses HL (1995) J Biol Chem 270: 29628-31 Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo. Okadome T, Oeda E, Saitoh M, Ichijo H, Moses HL, Miyazono K, Kawabata M (1996) J Biol Chem 271: 21687-90 Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. Ward SM, Desgrosellier JS, Zhuang X, Barnett JV, Galper JB (2002) J Biol Chem 277: 50183-9 Early events in valvulogenesis: a signaling perspective. Barnett JV, Desgrosellier JS (2003) Birth Defects Res C Embryo Today 69: 58-72 Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. Grau AM, Datta PK, Zi J, Halder SK, Beauchamp RD (2006) Cell Signal 18: 1041-50 Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. Townsend TA, Robinson JY, How T, DeLaughter DM, Blobe GC, Barnett JV (2012) Cell Signal 24: 247-56 Common pathways regulate Type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells. Clark CR, Robinson JY, Sanchez NS, Townsend TA, Arrieta JA, Merryman WD, Trykall DZ, Olivey HE, Hong CC, Barnett JV (2016) Cell Signal 28: 688-98 Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Lai YT, Beason KB, Brames GP, Desgrosellier JS, Cleggett MC, Shaw MV, Brown CB, Barnett JV (2000) Dev Biol 222: 1-11 Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Desgrosellier JS, Mundell NA, McDonnell MA, Moses HL, Barnett JV (2005) Dev Biol 280: 201-10 CBFa(AML/PEBP2)-related elements in the TGF-beta type I receptor promoter and expression with osteoblast differentiation. Ji C, Casinghino S, Chang DJ, Chen Y, Javed A, Ito Y, Hiebert SW, Lian JB, Stein GS, McCarthy TL, Centrella M (1998) J Cell Biochem 69: 353-63 Heritable forms of pulmonary arterial hypertension. Austin ED, Loyd JE (2013) Semin Respir Crit Care Med 34: 568-80 Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells. Compton LA, Potash DA, Mundell NA, Barnett JV (2006) Dev Dyn 235: 82-93 Zebrafish nma is involved in TGFbeta family signaling. Tsang M, Kim R, de Caestecker MP, Kudoh T, Roberts AB, Dawid IB (2000) Genesis 28: 47-57 Methods for the reliable induction of heterotopic ossification in the conditional mouse. Pan H, Fleming N, Hong CC, Mishina Y, Perrien DS (2020) J Musculoskelet Neuronal Interact 20: 149-159 The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. de Caestecker MP, Bottomley M, Bhattacharyya S, Payne TL, Roberts AB, Yelick PC (2002) Biochem Biophys Res Commun 293: 1556-65 Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR (2013) Bioorg Med Chem Lett 23: 3248-52
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