In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O (2013) Cell Metab 17: 372-85 Staphylococcal clumping with soluble fibrin mmonomer complexes. Lipiński B, Hawiger J, Jeljaszewicz J (1967) J Exp Med 126: 979-88 The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. McGowan CC, Cover TL, Blaser MJ (1994) Gastroenterology 107: 1573-8 cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA (2005) Circ Res 96: 100-9 exhibits heterogeneous siderophore production within the vertebrate host. Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM (2019) Proc Natl Acad Sci U S A 116: 21980-21982 Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH (2011) Diabetes 60: 416-26 Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH (2007) Diabetes 56: 1025-33 Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I (2008) Hypertension 51: 1531-6 The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. Dishy V, Sofowora G, Harris PA, Kandcer M, Zhan F, Wood AJ, Stein CM (2001) Clin Pharmacol Ther 70: 270-9 Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients. Aguer C, Mercier J, Man CY, Metz L, Bordenave S, Lambert K, Jean E, Lantier L, Bounoua L, Brun JF, Raynaud de Mauverger E, Andreelli F, Foretz M, Kitzmann M (2010) Diabetologia 53: 1151-63 Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA (2015) J Clin Endocrinol Metab 100: 4533-40 A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition. Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA (2016) J Clin Endocrinol Metab 101: 2751-8 Long-term follow-up after conversion from intravenous epoprostenol to oral therapy with bosentan or sildenafil in 13 patients with pulmonary arterial hypertension. Johnson RF, Loyd JE, Mullican AL, Fink CA, Robbins IM (2007) J Heart Lung Transplant 26: 363-9 Safety and efficacy of regional citrate anticoagulation during 8-hour sustained low-efficiency dialysis. Clark JA, Schulman G, Golper TA (2008) Clin J Am Soc Nephrol 3: 736-42 Effluent volume in continuous renal replacement therapy overestimates the delivered dose of dialysis. Claure-Del Granado R, Macedo E, Chertow GM, Soroko S, Himmelfarb J, Ikizler TA, Paganini EP, Mehta RL (2011) Clin J Am Soc Nephrol 6: 467-75 Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD (2004) Mol Pharmacol 65: 1462-74 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N (2002) J Lipid Res 43: 1220-35 Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation. Hemnes AR, Robbins IM (2009) Liver Transpl 15: 15-9 Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers. Dishy V, Harris PA, Pierce R, Prasad HC, Sofowora G, Bonar HL, Wood AJ, Stein CM (2004) Br J Clin Pharmacol 57: 209-12 Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis. Williams D, Fingleton B (2019) Clin Exp Metastasis 36: 211-224 Chiroptical spectroscopy of natural products: avoiding the aggregation effects of chiral carboxylic acids. Polavarapu PL, Donahue EA, Hammer KC, Raghavan V, Shanmugam G, Ibnusaud I, Nair DS, Gopinath C, Habel D (2012) J Nat Prod 75: 1441-50 Importance of solvation in understanding the chiroptical spectra of natural products in solution phase: garcinia acid dimethyl ester. Polavarapu PL, Scalmani G, Hawkins EK, Rizzo C, Jeirath N, Ibnusaud I, Habel D, Nair DS, Haleema S (2011) J Nat Prod 74: 321-8 Purification and properties of lysozyme produced by Staphylococcus aureus. Hawiger J (1968) J Bacteriol 95: 376-84 Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity. Johnsen VL, Belke DD, Hughey CC, Hittel DS, Hepple RT, Koch LG, Britton SL, Shearer J (2013) Physiol Genomics 45: 17-25 A single chiroptical spectroscopic method may not be able to establish the absolute configurations of diastereomers: dimethylesters of hibiscus and garcinia acids. Polavarapu PL, Donahue EA, Shanmugam G, Scalmani G, Hawkins EK, Rizzo C, Ibnusaud I, Thomas G, Habel D, Sebastian D (2011) J Phys Chem A 115: 5665-73 Subcellular localization of glutathione and thermal sensitivity. Freeman ML, Meredith MJ (1988) Radiat Res 115: 461-71 Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers. Barnett CF, Moreno-Ulloa A, Shiva S, Ramirez-Sanchez I, Taub PR, Su Y, Ceballos G, Dugar S, Schreiner G, Villarreal F (2015) Food Funct 6: 824-33 Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil. Zhu CB, Hewlett WA, Francis SH, Corbin JD, Blakely RD (2004) Eur J Pharmacol 504: 1-6 Choice and predictability in the preparation for barium enemas: a person-by-situation approach. Wallston BS, Smith RA, Wallston KA, King JE, Rye PD, Heim CR (1987) Res Nurs Health 10: 13-22 Sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of the heat shock-related protein 20 (HSP20). Tessier DJ, Komalavilas P, McLemore E, Thresher J, Brophy CM (2004) J Surg Res 118: 21-5 Acute effects of sildenafil in patients with primary pulmonary hypertension receiving epoprostenol. Kuhn KP, Wickersham NE, Robbins IM, Byrne DW (2004) Exp Lung Res 30: 135-45 Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Robbins IM, Hemnes AR, Gibbs JS, Christman BW, Howard L, Meehan S, Cabrita I, Gonzalez R, Oyler T, Zhao L, Du RH, Mendes LA, Wilkins MR (2011) Exp Lung Res 37: 26-34
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.