Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT (2014) Gastroenterology 146: 1739-51.e14 Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT (2011) Gastroenterology 141: 1696-708.e1-2 Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA, Wilson KT (2004) Cancer Res 64: 8521-5 Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA (2016) Oncogene 35: 5480-5488 Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT (2015) Oncogene 34: 3429-40 Hypothalamic peptidyl-glycine alpha-amidating monooxygenase: preliminary characterization. Emeson RB (1984) J Neurosci 4: 2604-13 Histamine directly and synergistically with lipopolysaccharide stimulates cyclooxygenase-2 expression and prostaglandin I(2) and E(2) production in human coronary artery endothelial cells. Tan X, Essengue S, Talreja J, Reese J, Stechschulte DJ, Dileepan KN (2007) J Immunol 179: 7899-906 Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Hong SK, Chaturvedi R, Piazuelo MB, Coburn LA, Williams CS, Delgado AG, Casero RA, Schwartz DA, Wilson KT (2010) Inflamm Bowel Dis 16: 1557-66 Recombinant 10-formyltetrahydrofolate dehydrogenase catalyses both dehydrogenase and hydrolase reactions utilizing the synthetic substrate 10-formyl-5,8-dideazafolate. Krupenko SA, Wagner C, Cook RJ (1995) Biochem J 306 ( Pt 3): 651-5 Expression, purification, and properties of the aldehyde dehydrogenase homologous carboxyl-terminal domain of rat 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, Wagner C, Cook RJ (1997) J Biol Chem 272: 10266-72 Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. Chaturvedi R, Cheng Y, Asim M, Bussière FI, Xu H, Gobert AP, Hacker A, Casero RA, Wilson KT (2004) J Biol Chem 279: 40161-73 Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, Wagner C (1999) J Biol Chem 274: 35777-84 Domain structure of rat 10-formyltetrahydrofolate dehydrogenase. Resolution of the amino-terminal domain as 10-formyltetrahydrofolate hydrolase. Krupenko SA, Wagner C, Cook RJ (1997) J Biol Chem 272: 10273-8 Cysteine 707 is involved in the dehydrogenase activity site of rat 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, Wagner C, Cook RJ (1995) J Biol Chem 270: 519-22 Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase. Cook RJ, Lloyd RS, Wagner C (1991) J Biol Chem 266: 4965-73 On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: connection between hydrolase and dehydrogenase mechanisms. Krupenko SA, Vlasov AP, Wagner C (2001) J Biol Chem 276: 24030-7 Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA, Wilson KT (2014) Amino Acids 46: 531-42 Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice. Pumford NR, Halmes NC, Martin BM, Cook RJ, Wagner C, Hinson JA (1997) J Pharmacol Exp Ther 280: 501-5 10-Formyltetrahydrofolate dehydrogenase: identification of the natural folate ligand, covalent labeling, and partial tryptic digestion. Wagner C, Briggs WT, Horne DW, Cook RJ (1995) Arch Biochem Biophys 316: 141-7 Enzymatic activities of rat liver cytosol 10-formyltetrahydrofolate dehydrogenase. Cook RJ, Wagner C (1995) Arch Biochem Biophys 321: 336-44 Overexpression of functional hydrolase domain of rat liver 10-formyltetrahydrofolate dehydrogenase in Escherichia coli. Krupenko SA, Wagner C (1998) Protein Expr Purif 14: 146-52 Baculovirus expression and purification of rat 10-formyltetrahydrofolate dehydrogenase. Krupenko SA, Horstman DA, Wagner C, Cook RJ (1995) Protein Expr Purif 6: 457-64
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.