Emergency coronary artery bypass surgery for percutaneous coronary interventions: changes in the incidence, clinical characteristics, and indications from 1979 to 2003. Yang EH, Gumina RJ, Lennon RJ, Holmes DR, Rihal CS, Singh M (2005) J Am Coll Cardiol 46: 2004-9 Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro AM, Cook EH, Murphy DL, Blakely RD (2008) J Clin Invest 118: 1544-52 CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation. Yuan W, Leisner TM, McFadden AW, Wang Z, Larson MK, Clark S, Boudignon-Proudhon C, Lam SC, Parise LV (2006) J Cell Biol 172: 169-75 Integrin cytoplasmic domains mediate inside-out signal transduction. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH (1994) J Cell Biol 124: 1047-59 Three-dimensional structure of the platelet integrin recognition segment of the fibrinogen gamma chain obtained by carrier protein-driven crystallization. Donahue JP, Patel H, Anderson WF, Hawiger J (1994) Proc Natl Acad Sci U S A 91: 12178-82 On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. Endenburg SC, Hantgan RR, Lindeboom-Blokzijl L, Lankhof H, Jerome WG, Lewis JC, Sixma JJ, de Groot PG (1995) Blood 86: 4158-65 A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor. Navarrete AM, Casari C, Legendre P, Marx I, Hu JR, Lenting PJ, Christophe OD, Denis CV (2012) Blood 120: 2723-32 Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature. Hallahan DE, Geng L, Cmelak AJ, Chakravarthy AB, Martin W, Scarfone C, Gonzalez A (2001) J Control Release 74: 183-91 Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Munnix IC, Kuijpers MJ, Auger J, Thomassen CM, Panizzi P, van Zandvoort MA, Rosing J, Bock PE, Watson SP, Heemskerk JW (2007) Arterioscler Thromb Vasc Biol 27: 2484-90 Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure. Hantgan RR, Stahle MC, Jerome WG, Nagaswami C, Weisel JW (2002) Thromb Haemost 87: 910-7 Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members. Denofrio JC, Yuan W, Temple BR, Gentry HR, Parise LV (2008) Thromb Haemost 100: 847-56 Mechanisms involved in platelet vessel wall interaction. Hawiger J (1995) Thromb Haemost 74: 369-72 Survival benefit with concomitant clopidogrel and glycoprotein IIb/IIIa inhibitor therapy at ad hoc percutaneous coronary intervention. Gumina RJ, Yang EH, Sandhu GS, Prasad A, Bresnahan JF, Lennon RJ, Rihal CS, Holmes DR, Singh M (2008) Mayo Clin Proc 83: 995-1001 Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. Sreedhara R, Itagaki I, Hakim RM (1996) Am J Kidney Dis 27: 355-64 Transcriptional regulation of alpha IIb integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element. Fong AM, Santoro SA (1994) J Biol Chem 269: 18441-7 The activation state of the integrin alpha IIb beta 3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation. Pelletier AJ, Kunicki T, Ruggeri ZM, Quaranta V (1995) J Biol Chem 270: 18133-40 PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE (2006) J Biol Chem 281: 26665-74 Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. Oliver KH, Duvernay MT, Hamm HE, Carneiro AM (2016) J Biol Chem 291: 20210-9 Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Holinstat M, Voss B, Bilodeau ML, Hamm HE (2007) Mol Pharmacol 71: 686-94 Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606. Oliver KH, Jessen T, Crawford EL, Chung CY, Sutcliffe JS, Carneiro AM (2014) Mol Pharmacol 85: 921-31 Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M (2012) Mol Pharmacol 81: 420-30 PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE (2007) Mol Pharmacol 71: 1399-406 Tickling the tails: cytoplasmic domain proteins that regulate integrin alphaIIbbeta3 activation. Leisner TM, Yuan W, DeNofrio JC, Liu J, Parise LV (2007) Curr Opin Hematol 14: 255-61 Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. Pfeiffer S, Zorn GL, Zhang JP, Giorgio TD, Robson SC, Azimzadeh AM, Pierson RN (2003) Transplantation 75: 953-9 Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway. Dong J, Dong J, Lin J, Wang B, He S, Wu C, Kushwaha KK, Mohabeer N, Su Y, Fang H, Huang K, Li D (2015) Cell Physiol Biochem 35: 160-74 Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood. Despotis GJ, Ikonomakou S, Levine V, Joiner-Maier D, Santoro SA, Joist JH (1997) Thromb Res 86: 205-19 The human PECAM1 gene maps to 17q23. Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (1996) Genomics 34: 229-32 New trials and therapies for acute myocardial infarction. Gumina RJ (2007) Med Clin North Am 91: 729-49; xii
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