The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide. Sánchez-Pedregal VM, Kubicek K, Meiler J, Lyothier I, Paterson I, Carlomagno T (2006) Angew Chem Int Ed Engl 45: 7388-94 Mechanisms of cytochrome P-450 catalysis. Guengerich FP, MacDonald TL (1990) FASEB J 4: 2453-9 Exhaled alkanes as indices of in vivo lipid peroxidation. Burk RF, Ludden TM (1989) Biochem Pharmacol 38: 1029-32 Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion. Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA (2019) Am J Physiol Endocrinol Metab 316: E646-E659 Dictyostelium cells migrate similarly on surfaces of varying chemical composition. McCann CP, Rericha EC, Wang C, Losert W, Parent CA (2014) PLoS One 9: e87981 Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal dihaloethanes. Wheeler JB, Stourman NV, Armstrong RN, Guengerich FP (2001) Chem Res Toxicol 14: 1107-17 Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. Guengerich FP, McCormick WA, Wheeler JB (2003) Chem Res Toxicol 16: 1493-9
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.