Human proinsulin-specific antigenic determinants identified by monoclonal antibodies. Madsen OD, Frank BH, Steiner DF (1984) Diabetes 33: 1012-6 Somatically mutated B cell pool provides precursors for insulin antibodies. Thomas JW, Hulbert C (1996) J Immunol 157: 763-71 The natural autoantibody repertoire of nonobese diabetic mice is highly active. Thomas JW, Kendall PL, Mitchell HG (2002) J Immunol 169: 6617-24 Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes. Acevedo-Suárez CA, Hulbert C, Woodward EJ, Thomas JW (2005) J Immunol 174: 827-33 Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice. Woodward EJ, Thomas JW (2005) J Immunol 175: 1073-9 Functional silencing is initiated and maintained in immature anti-insulin B cells. Henry RA, Acevedo-Suárez CA, Thomas JW (2009) J Immunol 182: 3432-9 Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene. Kendall PL, Moore DJ, Hulbert C, Hoek KL, Khan WN, Thomas JW (2009) J Immunol 183: 6403-12 Tolerant anti-insulin B cells are effective APCs. Kendall PL, Case JB, Sullivan AM, Holderness JS, Wells KS, Liu E, Thomas JW (2013) J Immunol 190: 2519-26 Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells. Bonami RH, Sullivan AM, Case JB, Steinberg HE, Hoek KL, Khan WN, Kendall PL (2014) J Immunol 192: 1459-70 Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes. Felton JL, Maseda D, Bonami RH, Hulbert C, Thomas JW (2018) J Immunol 201: 861-873 Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes. Williams JM, Bonami RH, Hulbert C, Thomas JW (2015) J Immunol 195: 853-64 Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene. Thomas JW (1992) Eur J Immunol 22: 2445-8 VH gene structure predicts a large potential anti-insulin repertoire. Mitchell HC, Thomas JW (1995) Mol Immunol 32: 311-21 NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. Bonami RH, Wolfle WT, Thomas JW, Kendall PL (2014) Mol Immunol 62: 321-8
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.