Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL (2002) Nat Med 8: 514-7 Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice. Babaev VR, Li L, Shah S, Fazio S, Linton MF, May JM (2010) Arterioscler Thromb Vasc Biol 30: 1751-7 Selective macrophage ascorbate deficiency suppresses early atherosclerosis. Babaev VR, Whitesell RR, Li L, Linton MF, Fazio S, May JM (2011) Free Radic Biol Med 50: 27-36 Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Harrison FE, May JM (2009) Free Radic Biol Med 46: 719-30 Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Harrison FE, Dawes SM, Meredith ME, Babaev VR, Li L, May JM (2010) Free Radic Biol Med 49: 821-9 Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Dixit S, Fessel JP, Harrison FE (2017) Free Radic Biol Med 112: 515-523 CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a. Qiao H, May JM (2011) Biochem J 440: 73-84 A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. Harrison FE (2012) J Alzheimers Dis 29: 711-26 Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE (2015) ACS Chem Neurosci 6: 570-81 Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung. Harrison FE, Best JL, Meredith ME, Gamlin CR, Borza DB, May JM, May JM (2012) PLoS One 7: e35623 Interaction of the transcription start site core region and transcription factor YY1 determine ascorbate transporter SVCT2 exon 1a promoter activity. Qiao H, May JM (2012) PLoS One 7: e35746 Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. Qiu S, Li L, Weeber EJ, May JM (2007) J Neurosci Res 85: 1046-56 Regulation of embryonic neurotransmitter and tyrosine hydroxylase protein levels by ascorbic acid. Meredith ME, May JM (2013) Brain Res 1539: 7-14 Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Meredith ME, Harrison FE, May JM (2011) Biochem Biophys Res Commun 414: 737-42 Oxidized LDL up-regulates the ascorbic acid transporter SVCT2 in endothelial cells. May JM, Li L, Qu ZC (2010) Mol Cell Biochem 343: 217-22 Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. Warner TA, Kang JQ, Kennard JA, Harrison FE (2015) Epilepsy Res 110: 20-5
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