Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Hill KE, Montine TJ, Motley AK, Li X, May JM, Burk RF (2003) Am J Clin Nutr 77: 1484-8 Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice. Babaev VR, Li L, Shah S, Fazio S, Linton MF, May JM (2010) Arterioscler Thromb Vasc Biol 30: 1751-7 Selective macrophage ascorbate deficiency suppresses early atherosclerosis. Babaev VR, Whitesell RR, Li L, Linton MF, Fazio S, May JM (2011) Free Radic Biol Med 50: 27-36 A combined deficiency of vitamins E and C causes severe central nervous system damage in guinea pigs. Burk RF, Christensen JM, Maguire MJ, Austin LM, Whetsell WO, May JM, Hill KE, Ebner FF (2006) J Nutr 136: 1576-81 Behavioral and monoamine changes following severe vitamin C deficiency. Ward MS, Lamb J, May JM, Harrison FE (2013) J Neurochem 124: 363-75 Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. Harrison FE, Yu SS, Van Den Bossche KL, Li L, May JM, McDonald MP (2008) J Neurochem 106: 1198-208 Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE (2015) ACS Chem Neurosci 6: 570-81 Vitamin C distribution and retention in the mouse brain. Harrison FE, Green RJ, Dawes SM, May JM (2010) Brain Res 1348: 181-6 Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Harrison FE, May JM, McDonald MP (2010) Pharmacol Biochem Behav 94: 543-52 Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. Warner TA, Kang JQ, Kennard JA, Harrison FE (2015) Epilepsy Res 110: 20-5
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.