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Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.
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- Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK
(2012) Cell 151: 138-52 - Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation.
Tavori H, Fan D, Blakemore JL, Yancey PG, Ding L, Linton MF, Fazio S
(2013) Circulation 127: 2403-13 - Response to letter regarding article, "Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms".
Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I, Fazio S
(2015) Circulation 131: e428 - Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent.
Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, Zhang J, Linton MF, Fazio S
(2011) Circulation 124: 454-64 - Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.
Mueller PA, Zhu L, Tavori H, Huynh K, Giunzioni I, Stafford JM, Linton MF, Fazio S
(2018) Circulation 138: 1850-1863 - Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.
Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I, Fazio S
(2014) Circulation 130: 431-41 - Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
Burleigh ME, Babaev VR, Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LJ, Morrow JD, Fazio S, Linton MF
(2002) Circulation 105: 1816-23 - Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice.
Babaev VR, Ding L, Reese J, Morrow JD, Breyer MD, Dey SK, Fazio S, Linton MF
(2006) Circulation 113: 108-17 - Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF
(2007) Circulation 116: 1404-12 - AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M
(2011) Cell Metab 13: 376-388 - Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel.
Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, Karayan L, Kastelein JJP, Kindt I, Lane SR, Leigh SE, Linton MF, Mata P, Neal WA, Nordestgaard BG, Santos RD, Harada-Shiba M, Sijbrands EJ, Stitziel NO, Yamashita S, Wilemon KA, Ledbetter DH, Rader DJ, Convened by the Familial Hypercholesterolemia Foundation
(2018) J Am Coll Cardiol 72: 662-680 - Proprotein convertase subtilisin/kexin type 9 as transducer of physiologic influences on cellular cholesterol: a case for resistin.
Fazio S, Linton MF
(2012) J Am Coll Cardiol 59: 1706-8 - Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV
(2001) J Clin Invest 107: 163-71 - Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor.
Linton MF, Hasty AH, Babaev VR, Fazio S
(1998) J Clin Invest 101: 1726-36 - Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RV
(2000) J Clin Invest 105: 711-9 - Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes.
Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, Boyadjian R, Bikineyeva A, Praticò D, Harrison DG, Hsueh WA
(2009) Circ Res 104: e42-54 - Control of very low-density lipoprotein secretion by N-ethylmaleimide-sensitive factor and miR-33.
Allen RM, Marquart TJ, Jesse JJ, Baldán A
(2014) Circ Res 115: 10-22 - Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.
Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI
(2015) Circ Res 117: 166-77 - Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.
Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H
(2019) Circ Res 124: e6-e19 - Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.
Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R, Welch CL, Hasty AH, Bornfeldt KE, Breslow JL, Tabas I, Tall AR
(2009) Circ Res 105: 1072-82 - Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids.
Pauta M, Rotllan N, Vales F, Fernandez-Hernando A, Allen RM, Ford DA, Marí M, Jiménez W, Baldán A, Morales-Ruiz M, Fernández-Hernando C
(2013) J Hepatol 59: 731-7 - miR-33 links SREBP-2 induction to repression of sterol transporters.
Marquart TJ, Allen RM, Ory DS, Baldán A
(2010) Proc Natl Acad Sci U S A 107: 12228-32 - Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus.
Stanic AK, Stein CM, Morgan AC, Fazio S, Linton MF, Wakeland EK, Olsen NJ, Major AS
(2006) Proc Natl Acad Sci U S A 103: 7018-23 - LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E
(2008) Proc Natl Acad Sci U S A 105: 8032-7 - Regulation of Selenium Metabolism and Transport.
Burk RF, Hill KE
(2015) Annu Rev Nutr 35: 109-34 - Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice.
Wilhelm AJ, Rhoads JP, Wade NS, Major AS
(2015) Ann Rheum Dis 74: 778-85 - Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL
(2008) Blood 111: 5316-25 - Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue.
Coenen KR, Gruen ML, Chait A, Hasty AH
(2007) Diabetes 56: 564-73 - Local effects of human PCSK9 on the atherosclerotic lesion.
Giunzioni I, Tavori H, Covarrubias R, Major AS, Ding L, Zhang Y, DeVay RM, Hong L, Fan D, Predazzi IM, Rashid S, Linton MF, Fazio S
(2016) J Pathol 238: 52-62 - Massive accumulation of neutral lipids in cells conditionally transformed by an activated H-ras oncogene.
Hirakawa T, Maruyama K, Kohl NE, Kodama T, Ruley HE
(1991) Oncogene 6: 289-95 - Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed.
Burk RF, Hill KE, Olson GE, Weeber EJ, Motley AK, Winfrey VP, Austin LM
(2007) J Neurosci 27: 6207-11 - Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.
Khanicheh E, Qi Y, Xie A, Mitterhuber M, Xu L, Mochizuki M, Daali Y, Jaquet V, Krause KH, Ruggeri ZM, Kuster GM, Lindner JR, Kaufmann BA
(2013) Arterioscler Thromb Vasc Biol 33: 2187-92 - Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation.
Yancey PG, Blakemore J, Ding L, Fan D, Overton CD, Zhang Y, Linton MF, Fazio S
(2010) Arterioscler Thromb Vasc Biol 30: 787-95 - Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity.
Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Chan L, Oka K, Thomas MJ, Sorci-Thomas MG
(2009) Arterioscler Thromb Vasc Biol 29: 843-9 - Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice.
Liu J, Thewke DP, Su YR, Linton MF, Fazio S, Sinensky MS
(2005) Arterioscler Thromb Vasc Biol 25: 174-9 - B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice.
Major AS, Fazio S, Linton MF
(2002) Arterioscler Thromb Vasc Biol 22: 1892-8 - Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.
Zhu L, Giunzioni I, Tavori H, Covarrubias R, Ding L, Zhang Y, Ormseth M, Major AS, Stafford JM, Linton MF, Fazio S
(2016) Arterioscler Thromb Vasc Biol 36: 1483-95 - Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
Babaev VR, Ding L, Zhang Y, May JM, Lin PC, Fazio S, Linton MF
(2016) Arterioscler Thromb Vasc Biol 36: 598-607 - Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).
White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJ
(2009) Arterioscler Thromb Vasc Biol 29: 1602-7 - Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes.
Babaev VR, Runner RP, Fan D, Ding L, Zhang Y, Tao H, Erbay E, Görgün CZ, Fazio S, Hotamisligil GS, Linton MF
(2011) Arterioscler Thromb Vasc Biol 31: 1283-90
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