Factor XI activation in a revised model of blood coagulation. Gailani D, Broze GJ (1991) Science 253: 909-12 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M (2013) Thromb Haemost 110: 569-81 Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin. Temple KJ, Duvernay MT, Young SE, Wen W, Wu W, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW (2016) J Med Chem 59: 7690-5 PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE (2006) J Biol Chem 281: 26665-74 Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen. Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA (2009) J Biol Chem 284: 34640-7 Protease-activated receptor-2 signaling triggers dendritic cell development. Fields RC, Schoenecker JG, Hart JP, Hoffman MR, Pizzo SV, Lawson JH (2003) Am J Pathol 162: 1817-22 Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets. Duvernay M, Young S, Gailani D, Schoenecker J, Hamm HE, Hamm H (2013) Mol Pharmacol 83: 781-92 Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Holinstat M, Voss B, Bilodeau ML, Hamm HE (2007) Mol Pharmacol 71: 686-94 PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE (2007) Mol Pharmacol 71: 1399-406 Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets. Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE (2017) Mol Pharmacol 91: 39-47 Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions. Bilodeau ML, Hamm HE (2007) J Pharmacol Exp Ther 322: 778-88 Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets. Young SE, Duvernay MT, Schulte ML, Lindsley CW, Hamm HE (2013) PLoS One 8: e65528 Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation. Duvernay MT, Matafonov A, Lindsley CW, Hamm HE (2015) Biochemistry 54: 5578-88 Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles. Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW (2016) Bioorg Med Chem Lett 26: 5481-5486 Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions. Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJT (2019) Platelets 30: 126-135
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