Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Kuss SK, Best GT, Etheredge CA, Pruijssers AJ, Frierson JM, Hooper LV, Dermody TS, Pfeiffer JK (2011) Science 334: 249-52 Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. Johansson C, Wetzel JD, He J, Mikacenic C, Dermody TS, Kelsall BL (2007) J Exp Med 204: 1349-58 Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS (2005) J Clin Invest 115: 2341-50 Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. Barton ES, Youree BE, Ebert DH, Forrest JC, Connolly JL, Valyi-Nagy T, Washington K, Wetzel JD, Dermody TS (2003) J Clin Invest 111: 1823-33 A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS (2007) Cell Host Microbe 1: 147-57 The Nogo receptor NgR1 mediates infection by mammalian reovirus. Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM, Dermody TS (2014) Cell Host Microbe 15: 681-91 Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Antar AA, Konopka JL, Campbell JA, Henry RA, Perdigoto AL, Carter BD, Pozzi A, Abel TW, Dermody TS (2009) Cell Host Microbe 5: 59-71 Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Boehme KW, Guglielmi KM, Dermody TS (2009) Proc Natl Acad Sci U S A 106: 19986-91 Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. Excoffon KJ, Guglielmi KM, Wetzel JD, Gansemer ND, Campbell JA, Dermody TS, Zabner J (2008) J Infect Dis 197: 1189-97 Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O'Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS (2004) J Infect Dis 189: 1664-75 Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. Tai JH, Williams JV, Edwards KM, Wright PF, Crowe JE, Dermody TS (2005) J Infect Dis 191: 1221-4 Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. Stencel-Baerenwald J, Reiss K, Blaum BS, Colvin D, Li XN, Abel T, Boyd K, Stehle T, Dermody TS (2015) MBio 6: e02356 Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. Brown JJ, Short SP, Stencel-Baerenwald J, Urbanek K, Pruijssers AJ, McAllister N, Ikizler M, Taylor G, Aravamudhan P, Khomandiak S, Jabri B, Williams CS, Dermody TS (2018) J Virol 92: Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice. Haller BL, Barkon ML, Li XY, Hu WM, Wetzel JD, Dermody TS, Virgin HW (1995) J Virol 69: 3933-7 Effects of the route of infection on immunoglobulin G subclasses and specificity of the reovirus-specific humoral immune response. Major AS, Cuff CF (1996) J Virol 70: 5968-74 Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures. Morrison LA, Fields BN, Dermody TS (1993) J Virol 67: 3019-26 Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL (1997) J Virol 71: 2100-6 Enhanced mucosal and systemic immune responses to intestinal reovirus infection in beta2-microglobulin-deficient mice. Major AS, Cuff CF (1997) J Virol 71: 5782-9 Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly. Baer GS, Ebert DH, Chung CJ, Erickson AH, Dermody TS (1999) J Virol 73: 9532-43 Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2). Poggioli GJ, Dermody TS, Tyler KL (2001) J Virol 75: 7429-34 Virion disassembly is required for apoptosis induced by reovirus. Connolly JL, Dermody TS (2002) J Virol 76: 1632-41 Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. Wetzel JD, Barton ES, Chappell JD, Baer GS, Mochow-Grundy M, Rodgers SE, Shyr Y, Powers AC, Thomas JW, Dermody TS (2006) J Virol 80: 3078-82 Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. O'Donnell SM, Holm GH, Pierce JM, Tian B, Watson MJ, Chari RS, Ballard DW, Brasier AR, Dermody TS (2006) J Virol 80: 1077-86 Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. Danthi P, Kobayashi T, Holm GH, Hansberger MW, Abel TW, Dermody TS (2008) J Virol 82: 161-72 Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. Johnson EM, Doyle JD, Wetzel JD, McClung RP, Katunuma N, Chappell JD, Washington MK, Dermody TS (2009) J Virol 83: 9630-40 Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. Holm GH, Pruijssers AJ, Li L, Danthi P, Sherry B, Dermody TS (2010) J Virol 84: 6900-8 The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. Boehme KW, Frierson JM, Konopka JL, Kobayashi T, Dermody TS (2011) J Virol 85: 11781-90 A single-amino-acid polymorphism in reovirus protein μ2 determines repression of interferon signaling and modulates myocarditis. Irvin SC, Zurney J, Ooms LS, Chappell JD, Dermody TS, Sherry B (2012) J Virol 86: 2302-11 Apoptosis induction influences reovirus replication and virulence in newborn mice. Pruijssers AJ, Hengel H, Abel TW, Dermody TS (2013) J Virol 87: 12980-9 Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells. Gonzalez-Hernandez MB, Liu T, Payne HC, Stencel-Baerenwald JE, Ikizler M, Yagita H, Dermody TS, Williams IR, Wobus CE (2014) J Virol 88: 6934-43 Nonstructural protein σ1s mediates reovirus-induced cell cycle arrest and apoptosis. Boehme KW, Hammer K, Tollefson WC, Konopka-Anstadt JL, Kobayashi T, Dermody TS (2013) J Virol 87: 12967-79 Genetic determinants of reovirus pathogenesis in a murine model of respiratory infection. Nygaard RM, Lahti L, Boehme KW, Ikizler M, Doyle JD, Dermody TS, Schiff LA (2013) J Virol 87: 9279-89 Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. Dermody TS, Nibert ML, Wetzel JD, Tong X, Fields BN (1993) J Virol 67: 2055-63 Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability. Wilson GJ, Wetzel JD, Puryear W, Bassel-Duby R, Dermody TS (1996) J Virol 70: 6598-606 Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. Wetzel JD, Wilson GJ, Baer GS, Dunnigan LR, Wright JP, Tang DS, Dermody TS (1997) J Virol 71: 1362-9 Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS (2015) J Virol 89: 8701-12 Structural and Functional Features of the Reovirus σ1 Tail. Dietrich MH, Ogden KM, Long JM, Ebenhoch R, Thor A, Dermody TS, Stehle T (2018) J Virol 92: Mucosal immunity to reovirus infection. Major AS, Rubin DH, Cuff CF (1998) Curr Top Microbiol Immunol 233: 163-77 Apoptosis and the cytopathic effects of reovirus. Oberhaus SM, Dermody TS, Tyler KL (1998) Curr Top Microbiol Immunol 233: 23-49 Cellular and humoral immunity to reovirus infection. Virgin HW, Dermody TS, Tyler KL (1998) Curr Top Microbiol Immunol 233: 147-61
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.